ptpro protein tyrosine phosphatase receptor type O [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptproprovided by ZNC
Official Full Name: protein tyrosine phosphatase receptor type Oprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070424-54
See related: AllianceGenome:ZFIN:ZDB-GENE-070424-54
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158179
Summary: Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within cerebellum morphogenesis and regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; eye; optic cup; optic vesicle; and tail bud. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (183687..211904, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (57509..85726)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ptpro regulates cerebellar formation during zebrafish development through modulating Fgf signaling.
Title: Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

G47780 (e-PCR)
- UniSTS:108549

G46469 (e-PCR)
- UniSTS:107271

fj64a08.x1 (e-PCR)
- UniSTS:199729

G39854 (e-PCR)
- UniSTS:64849

G45583 (e-PCR)
- UniSTS:106385

G46107 (e-PCR)
- UniSTS:106909

G45167 (e-PCR)
- UniSTS:105969

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase O

Names: glomerular epithelial protein 1

NP_001077283.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083814.1 → NP_001077283.1 receptor-type tyrosine-protein phosphatase O precursor

See identical proteins and their annotated locations for NP_001077283.1

Status: PROVISIONAL

Source sequence(s)

BC134806

UniProtKB/TrEMBL

A4IFW3

Conserved Domains (5) summary

smart00060
Location:744 → 812

FN3; Fibronectin type 3 domain

smart00194
Location:959 → 1215

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:986 → 1215

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:547 → 647

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:362 → 423

fn3; Fibronectin type III domain