Cdhr2 cadherin-related family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdhr2provided by RGD
Official Full Name: cadherin-related family member 2provided by RGD
Primary source: RGD:1560576
See related: Ensembl:ENSRNOG00000017917 AllianceGenome:RGD:1560576
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pcdh24; RGD1560576
Summary: Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; intermicrovillar adhesion; and negative regulation of cell growth involved in contact inhibition. Predicted to be located in apical plasma membrane; brush border membrane; and microvillus membrane. Predicted to be spanning component of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human CDHR2 (cadherin related family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 180.2), Brain (RPKM 28.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9881979..9917698, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9876853..9913356, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10415044..10450589, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brush border assembly	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in intermicrovillar adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in contact inhibition	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus length	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-related family member 2

Names: protocadherin 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427596.1 → NP_001414525.1 cadherin-related family member 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

D3ZAN2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

9881979..9917698 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096513.2 → XP_038952441.1 cadherin-related family member 2 isoform X2

Conserved Domains (1) summary

cd11304
Location:95 → 192

Cadherin_repeat; Cadherin tandem repeat domain
XM_039096512.2 → XP_038952440.1 cadherin-related family member 2 isoform X1

UniProtKB/TrEMBL

A6KAX4

Conserved Domains (1) summary

cd11304
Location:338 → 435

Cadherin_repeat; Cadherin tandem repeat domain