gc2 guanylyl cyclase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gc2provided by ZNC
Official Full Name: guanylyl cyclase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-011128-8
See related: Ensembl:ENSDARG00000018329 AllianceGenome:ZFIN:ZDB-GENE-011128-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: RETGC-2
Summary: Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within several processes, including cyclic nucleotide biosynthetic process; protein phosphorylation; and visual perception. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in retina and retinal outer nuclear layer. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (51267545..51297609, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (50992592..51019333, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: retinal guanylyl cyclase 2

Names: Gucy2f

NP_001103165.1

EC 4.6.1.2

XP_017212295.1

EC 4.6.1.2

XP_021333059.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109695.1 → NP_001103165.1 retinal guanylyl cyclase 2

See identical proteins and their annotated locations for NP_001103165.1

Status: PROVISIONAL

Source sequence(s)

CR381676

UniProtKB/TrEMBL

A0A8M1NEV9, E7F111

Related

ENSDARP00000089419.1, ENSDART00000098648.3

Conserved Domains (7) summary

cd06371
Location:59 → 440

PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues

PHA02988
Location:542 → 809

PHA02988; hypothetical protein; Provisional

smart00044
Location:848 → 1040

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14043
Location:551 → 815

PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D

pfam00211
Location:875 → 1062

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:76 → 417

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:824 → 869

HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

51267545..51297609 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477384.1 → XP_021333059.1 retinal guanylyl cyclase 2 isoform X1

UniProtKB/TrEMBL

A0A8M9Q7H0

Conserved Domains (4) summary

cd06371
Location:59 → 440

PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues

smart00044
Location:848 → 1040

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14043
Location:551 → 815

PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D

pfam07701
Location:824 → 869

HNOBA; Heme NO binding associated
XM_017356806.2 → XP_017212295.1 retinal guanylyl cyclase 2 isoform X2

UniProtKB/TrEMBL

A0A8M1NEV9, E7F111

Related

ENSDARP00000143153.1, ENSDART00000174174.2

Conserved Domains (7) summary

cd06371
Location:59 → 440

PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues

PHA02988
Location:542 → 809

PHA02988; hypothetical protein; Provisional

smart00044
Location:848 → 1040

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14043
Location:551 → 815

PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D

pfam00211
Location:875 → 1062

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:76 → 417

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:824 → 869

HNOBA; Heme NO binding associated