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    prkab1b protein kinase, AMP-activated, beta 1 non-catalytic subunit, b [ Danio rerio (zebrafish) ]

    Gene ID: 335232, updated on 27-Mar-2024

    Summary

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    Official Symbol
    prkab1bprovided by ZNC
    Official Full Name
    protein kinase, AMP-activated, beta 1 non-catalytic subunit, bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7172
    See related
    Ensembl:ENSDARG00000046143 AllianceGenome:ZFIN:ZDB-GENE-030131-7172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    prkab1; zgc:56652; zgc:76975; wu:fk93d05; wu:fw87e09
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in regulation of primary metabolic process and signal transduction. Predicted to act upstream of or within fatty acid biosynthetic process; phosphorylation; and regulation of catalytic activity. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See prkab1b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (39674707..39703747)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (39640933..39669973)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-63d15.12 Neighboring gene transmembrane protein 233-like Neighboring gene phospholipase A2, group IB (pancreas) Neighboring gene asialoglycoprotein receptor-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of Wnt16 Leads to Skeletal Deformities and Downregulation of Bone Developmental Pathway in Zebrafish. Qu X, et al. Int J Mol Sci, 2021 Jun 22. PMID 34206401, Free PMC Article
    2. Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by Metabonomics. Ma Y, et al. Front Pharmacol, 2019. PMID 31780949, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5'-AMP-activated protein kinase subunit beta-1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328554.1 → NP_001315483.1  5'-AMP-activated protein kinase subunit beta-1b

      Status: VALIDATED

      Source sequence(s)
      BX005328, EH456078, EH461046, EH508306
      UniProtKB/TrEMBL
      A0A8M1PAF8, Q6NY31
      Related
      ENSDARP00000107882.2, ENSDART00000126301.4
      Conserved Domains (2) summary
      smart01010
      Location:171 → 260
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:68 → 151
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    2. NM_214713.2 → NP_999878.1  5'-AMP-activated protein kinase subunit beta-1b

      See identical proteins and their annotated locations for NP_999878.1

      Status: VALIDATED

      Source sequence(s)
      BX005328, EH456078, EH461046, EH508306
      UniProtKB/TrEMBL
      A0A8M1PAF8, Q6NY31
      Related
      ENSDARP00000040329.5, ENSDART00000040330.7
      Conserved Domains (2) summary
      smart01010
      Location:171 → 260
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:68 → 151
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      39674707..39703747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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