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    cd68 CD68 molecule [ Danio rerio (zebrafish) ]

    Gene ID: 100000085, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cd68provided by ZNC
    Official Full Name
    CD68 moleculeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1312
    See related
    Ensembl:ENSDARG00000055504 AllianceGenome:ZFIN:ZDB-GENE-030131-1312
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb66f03; wu:fb66f03; si:ch211-212k18.7
    Summary
    Predicted to be involved in establishment of protein localization to organelle. Predicted to be located in lysosome and membrane. Predicted to be integral component of membrane. Predicted to be active in late endosome membrane; lysosomal membrane; and plasma membrane. Orthologous to human CD68 (CD68 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See cd68 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (19482914..19491627)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (19230946..19239659)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene NACHT domain- and WD repeat-containing protein 1-like Neighboring gene si:ch211-212k18.6 Neighboring gene si:ch211-212k18.8 Neighboring gene si:ch211-212k18.9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Oosterhof N, et al. Glia, 2017 Jan. PMID 27757989, Free PMC Article
    2. Chaperone-Mediated Autophagy in the Light of Evolution: Insight from Fish. Lescat L, et al. Mol Biol Evol, 2020 Oct 1. PMID 32437540
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in establishment of protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosome-associated membrane glycoprotein 3; macrosialin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      19482914..19491627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002662803.5 → XP_002662849.1  macrosialin

      UniProtKB/TrEMBL
      A0A8M1RLX4, E7F3A5
      Related
      ENSDARP00000072334.4, ENSDART00000077868.6
      Conserved Domains (1) summary
      pfam01299
      Location:105 → 300
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394683.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      204993..213850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471872.1 → XP_021327547.1  macrosialin

      UniProtKB/TrEMBL
      A0A2R8QGA4, A0A8M9P9G2
      Conserved Domains (1) summary
      pfam01299
      Location:105 → 300
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    Nucleotide Protein
    Heading Accession and Version

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