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    cnmd chondromodulin [ Danio rerio (zebrafish) ]

    Gene ID: 791772, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cnmdprovided by ZNC
    Official Full Name
    chondromodulinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010713-1
    See related
    Ensembl:ENSDARG00000100133 AllianceGenome:ZFIN:ZDB-GENE-010713-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    chm1; cb298; lect1; fb55b05; wu:fb55b05
    Summary
    Predicted to be involved in several processes, including endothelial cell morphogenesis; negative regulation of endothelial cell proliferation; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to act upstream of or within cartilage development and cell differentiation. Predicted to be located in endomembrane system; extracellular region; and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including cartilage element; cranium; head mesenchyme; hypochord; and lapillus. Orthologous to human CNMD (chondromodulin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See cnmd in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (53725128..53744248)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (54185533..54204653)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene protocadherin 8 Neighboring gene si:ch211-199f5.1 Neighboring gene endothelin receptor type Bb Neighboring gene component of oligomeric golgi complex 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis. Sachdev SW, et al. Mech Dev, 2001 Jul. PMID 11429291
    2. Expression of two novel zebrafish iroquois homologues (ziro1 and ziro5) during early development of axial structures and central nervous system. Wang X, et al. Mech Dev, 2001 Jul. PMID 11429297
    3. Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation. Xu P, et al. Elife, 2021 Jan 27. PMID 33501917, Free PMC Article
    4. Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher. Clément A, et al. PLoS Genet, 2008 Jul 25. PMID 18654627, Free PMC Article
    5. barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches. Sperber SM, et al. Dev Biol, 2008 Sep 1. PMID 18590717, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC76820

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte cell-derived chemotaxin 1
    Names
    chM-I
    chondromodulin-1
    chondromodulin-I
    leukocyte cell derived chemotaxin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126448.2 → NP_001119920.2  leukocyte cell-derived chemotaxin 1

      Status: VALIDATED

      Source sequence(s)
      EH585281, FP102998
      UniProtKB/Swiss-Prot
      P58239
      UniProtKB/TrEMBL
      A0A0R4IIF8, A0A8M1NGS2
      Related
      ENSDARP00000138747.1, ENSDART00000169062.2
      Conserved Domains (1) summary
      smart01039
      Location:73 → 156
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      53725128..53744248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305008.3 → XP_009303283.1  leukocyte cell-derived chemotaxin 1 isoform X1

      UniProtKB/Swiss-Prot
      P58239
      UniProtKB/TrEMBL
      A0A0R4IMQ2, A0A8M3BCN7
      Related
      ENSDARP00000136347.1, ENSDART00000165991.2
      Conserved Domains (1) summary
      smart01039
      Location:73 → 156
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58239.1 GenPept UniProtKB/Swiss-Prot:P58239

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.