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    Hnrnpr heterogeneous nuclear ribonucleoprotein R [ Rattus norvegicus (Norway rat) ]

    Gene ID: 319110, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Hnrnprprovided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Rprovided by RGD
    Primary source
    RGD:631348
    See related
    Ensembl:ENSRNOG00000011910 AllianceGenome:RGD:631348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrpr
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in circadian rhythm; mRNA destabilization; and negative regulation of catalytic activity. Located in several cellular components, including dendrite; distal axon; and nucleus. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 292.0), Lung (RPKM 237.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpr in Genome Data Viewer
    Location:
    5q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153826482..153872272)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148542999..148574888)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154668194..154699967)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy chain 6 like 1 Neighboring gene zinc finger protein 46 Neighboring gene uncharacterized LOC120103181 Neighboring gene 5-hydroxytryptamine receptor 1D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The expression pattern of heterogeneous nuclear ribonucleoprotein R in rat retina. Peng ZY, et al. Neurochem Res, 2009 Jun. PMID 19015982
    2. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. Hassfeld W, et al. Nucleic Acids Res, 1998 Jan 15. PMID 9421497, Free PMC Article
    3. hnRNP-R regulates the PMA-induced c-fos expression in retinal cells. Huang J, et al. Cell Mol Biol Lett, 2008. PMID 18197392, Free PMC Article
    4. Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons. Rossoll W, et al. J Cell Biol, 2003 Nov 24. PMID 14623865, Free PMC Article
    5. Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation. Kim TD, et al. Mol Cell Biol, 2005 Apr. PMID 15798208, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175603.3 → NP_783193.2  heterogeneous nuclear ribonucleoprotein R

      See identical proteins and their annotated locations for NP_783193.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1LUZ6, Q566E4, Q811S1
      Conserved Domains (2) summary
      TIGR01648
      Location:106 → 627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21067
      Location:27 → 110
      NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153826482..153872272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287850.1 → XP_063143920.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    2. XM_063287861.1 → XP_063143931.1  heterogeneous nuclear ribonucleoprotein R isoform X6

    3. XM_063287858.1 → XP_063143928.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    4. XM_063287857.1 → XP_063143927.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    5. XM_063287863.1 → XP_063143933.1  heterogeneous nuclear ribonucleoprotein R isoform X8

    6. XM_063287859.1 → XP_063143929.1  heterogeneous nuclear ribonucleoprotein R isoform X5

    7. XM_063287854.1 → XP_063143924.1  heterogeneous nuclear ribonucleoprotein R isoform X2

      UniProtKB/TrEMBL
      F1LUZ6, Q566E4

    8. XM_039110146.2 → XP_038966074.1  heterogeneous nuclear ribonucleoprotein R isoform X7

      UniProtKB/TrEMBL
      Q811S1
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    9. XM_063287862.1 → XP_063143932.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    10. XM_063287851.1 → XP_063143921.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    11. XM_063287855.1 → XP_063143925.1  heterogeneous nuclear ribonucleoprotein R isoform X2

      UniProtKB/TrEMBL
      F1LUZ6, Q566E4

    12. XM_063287856.1 → XP_063143926.1  heterogeneous nuclear ribonucleoprotein R isoform X2

      UniProtKB/TrEMBL
      F1LUZ6, Q566E4

    13. XM_063287852.1 → XP_063143922.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    14. XM_063287860.1 → XP_063143930.1  heterogeneous nuclear ribonucleoprotein R isoform X5

    15. XM_063287853.1 → XP_063143923.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    RNA

    1. XR_010066404.1 RNA Sequence

    2. XR_010066405.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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