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    CGB7 chorionic gonadotropin subunit beta 7 [ Homo sapiens (human) ]

    Gene ID: 94027, updated on 23-Nov-2023

    Summary

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    Official Symbol
    CGB7provided by HGNC
    Official Full Name
    chorionic gonadotropin subunit beta 7provided by HGNC
    Primary source
    HGNC:HGNC:16451
    See related
    Ensembl:ENSG00000196337 MIM:608826; AllianceGenome:HGNC:16451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGB6; CG-beta-a
    Summary
    This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in placenta (RPKM 5.5), skin (RPKM 1.3) and 1 other tissue See more
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    Genomic context

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    See CGB7 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49054274..49057749, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52049059..52052533, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49557531..49561006, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurotrophin 4 pseudogene Neighboring gene chorionic gonadotropin subunit beta 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49557355-49557905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49558580-49559433 Neighboring gene uncharacterized LOC124904739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49559434-49560286 Neighboring gene neurotrophin 4 Neighboring gene potassium voltage-gated channel subfamily A member 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49574847-49575348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49575349-49575848

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit. Biskup K, et al. Glycoconj J, 2020 Oct. PMID 32767150, Free PMC Article
    2. Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin. Mise T, et al. J Biol Chem, 1981 Jul 10. PMID 7240231
    3. Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit. Carlsen RB, et al. J Biol Chem, 1973 Oct 10. PMID 4795659
    4. The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene. Sohr S, et al. Cell Cycle, 2011 Nov 1. PMID 22032922, Free PMC Article
    5. Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Lunardi-Iskandar Y, et al. Nature, 1995 May 4. PMID 7723844

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit.
      Title: N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit.
    2. Expression of the CGB7 gene is upregulated upon p53 induction in human HFF, HCT116 and DLD1 cells as well as in cell preparations enriched in human primary first-trimester trophoblasts.
      Title: The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35403, FLJ43118

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in female gamete generation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    choriogonadotropin subunit beta 7
    Names
    chorionic gonadotropin beta 7 subunit
    chorionic gonadotropin beta subunit 7
    chorionic gonadotropin, beta polypeptide 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385261.1 → NP_001372190.1  choriogonadotropin subunit beta 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC008687
      Consensus CDS
      CCDS33071.1
      UniProtKB/Swiss-Prot
      P0DN87
      UniProtKB/TrEMBL
      A0A0F7RPU2, A0A0F7RQF0
      Related
      ENSP00000507822.1, ENST00000684222.1
      Conserved Domains (1) summary
      smart00068
      Location:25 → 131
      GHB; Glycoprotein hormone beta chain homologues

    2. NM_033142.2 → NP_149133.1  choriogonadotropin subunit beta 7 precursor

      See identical proteins and their annotated locations for NP_149133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC008687
      Consensus CDS
      CCDS33071.1
      UniProtKB/Swiss-Prot
      P0DN87
      UniProtKB/TrEMBL
      A0A0F7RPU2, A0A0F7RQF0
      Related
      ENSP00000469076.1, ENST00000596965.5
      Conserved Domains (1) summary
      smart00068
      Location:25 → 131
      GHB; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49054274..49057749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52049059..52052533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DN87.1 GenPept UniProtKB/Swiss-Prot:P0DN87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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