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    VSIG10L2 V-set and immunoglobulin domain containing 10 like 2 [ Homo sapiens (human) ]

    Gene ID: 338667, updated on 11-Apr-2024

    Summary

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    Official Symbol
    VSIG10L2provided by HGNC
    Official Full Name
    V-set and immunoglobulin domain containing 10 like 2provided by HGNC
    Primary source
    HGNC:HGNC:27879
    See related
    Ensembl:ENSG00000283703 AllianceGenome:HGNC:27879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be active in cell-cell junction. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in skin (RPKM 3.2), spleen (RPKM 0.6) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See VSIG10L2 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125946044..125956319)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125974898..125985173)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125815939..125826214)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene HYLS1 centriolar and ciliogenesis associated Neighboring gene pseudouridine synthase 3 Neighboring gene DEAD-box helicase 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125802853-125803806 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:125805158-125805722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4045 Neighboring gene cell adhesion associated, oncogene regulated Neighboring gene VISTA enhancer hs1641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4047 Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-set and immunoglobulin domain-containing protein 10-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365077.2 → NP_001352006.1  V-set and immunoglobulin domain-containing protein 10-like 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP000842
      Consensus CDS
      CCDS91619.1
      UniProtKB/Swiss-Prot
      P0DP72
      UniProtKB/TrEMBL
      A0A8I5KPR9
      Related
      ENSP00000509422.1, ENST00000686984.1
      Conserved Domains (3) summary
      smart00410
      Location:508 → 594
      IG_like; Immunoglobulin like
      pfam00041
      Location:598 → 689
      fn3; Fibronectin type III domain
      pfam13927
      Location:241 → 312
      Ig_3; Immunoglobulin domain

    2. NM_001391971.1 → NP_001378900.1  V-set and immunoglobulin domain-containing protein 10-like 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP000842
      UniProtKB/TrEMBL
      A0A1W2PP72
      Related
      ENSP00000491366.1, ENST00000640497.1

    3. NM_001391972.1 → NP_001378901.1  V-set and immunoglobulin domain-containing protein 10-like 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP000842
      Related
      ENST00000638511.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      125946044..125956319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      125974898..125985173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DP72.1 GenPept UniProtKB/Swiss-Prot:P0DP72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials