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    Cdhr5 cadherin-related family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 72040, updated on 12-May-2024

    Summary

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    Official Symbol
    Cdhr5provided by MGI
    Official Full Name
    cadherin-related family member 5provided by MGI
    Primary source
    MGI:MGI:1919290
    See related
    Ensembl:ENSMUSG00000025497 AllianceGenome:MGI:1919290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mucdhl; Mupcdh; 1810074H01Rik
    Summary
    Predicted to enable beta-catenin binding activity; calcium ion binding activity; and cell adhesion molecule binding activity. Predicted to be involved in cell adhesion; intermicrovillar adhesion; and regulation of microvillus length. Predicted to act upstream of or within cell differentiation. Predicted to be located in apical plasma membrane; cell projection membrane; and clathrin-coated pit. Predicted to be spanning component of plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in liver; lung; metanephros; placenta; and yolk sac. Orthologous to human CDHR5 (cadherin related family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 477.0), small intestine adult (RPKM 353.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdhr5 in Genome Data Viewer
    Location:
    7 F5; 7 86.58 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140848993..140856708, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141269080..141276795, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11376 Neighboring gene predicted gene, 51460 Neighboring gene PHD and ring finger domains 1 Neighboring gene interferon regulatory factor 7 Neighboring gene secretin Neighboring gene STARR-seq mESC enhancer starr_20485 Neighboring gene dopamine receptor D4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms. Beck M, et al. Oncogene, 2021 Jan. PMID 33188295
    2. mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains. Goldberg M, et al. J Biol Chem, 2000 Aug 11. PMID 10801787
    3. Biallelic expression of HRAS and MUCDHL in human and mouse. Goldberg M, et al. Hum Genet, 2003 Apr. PMID 12589428
    4. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Lü J, et al. Dev Biol, 2004 Sep 15. PMID 15328023
    5. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Garrison WD, et al. Gastroenterology, 2006 Apr. PMID 16618389, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in brush border assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intermicrovillar adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microvillus length ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-related family member 5
    Names
    mu-protocadherin
    mucin and cadherin-like protein
    mucin-like protocadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114322.1 → NP_001107794.1  cadherin-related family member 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001107794.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK027913, BG063646
      Consensus CDS
      CCDS52442.1
      UniProtKB/Swiss-Prot
      Q8CEJ3, Q8VHF2, Q9D8I9
      UniProtKB/TrEMBL
      A0PJK7
      Related
      ENSMUSP00000127292.2, ENSMUST00000167263.9
      Conserved Domains (1) summary
      cd11304
      Location:133 → 229
      Cadherin_repeat; Cadherin tandem repeat domain

    2. NM_028069.3 → NP_082345.1  cadherin-related family member 5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_082345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C- termini compared to isoform 1.
      Source sequence(s)
      AK007988, BB609487
      Consensus CDS
      CCDS22006.1
      UniProtKB/Swiss-Prot
      Q8CEJ3, Q8VHF2, Q9D8I9
      Related
      ENSMUSP00000079484.6, ENSMUST00000080654.7
      Conserved Domains (1) summary
      cd11304
      Location:133 → 229
      Cadherin_repeat; Cadherin tandem repeat domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140848993..140856708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536260.4 → XP_006536323.1  cadherin-related family member 5 isoform X1

      See identical proteins and their annotated locations for XP_006536323.1

      UniProtKB/Swiss-Prot
      Q8CEJ3, Q8VHF2, Q9D8I9
      Conserved Domains (1) summary
      cd11304
      Location:133 → 229
      Cadherin_repeat; Cadherin tandem repeat domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHF2.1 GenPept UniProtKB/Swiss-Prot:Q8VHF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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