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    TNFRSF19 TNF receptor superfamily member 19 [ Homo sapiens (human) ]

    Gene ID: 55504, updated on 10-Mar-2024

    Summary

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    Official Symbol
    TNFRSF19provided by HGNC
    Official Full Name
    TNF receptor superfamily member 19provided by HGNC
    Primary source
    HGNC:HGNC:11915
    See related
    Ensembl:ENSG00000127863 MIM:606122; AllianceGenome:HGNC:11915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAJ; TROY; TRADE; TAJ-alpha
    Summary
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 37.6), prostate (RPKM 12.9) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNFRSF19 in Genome Data Viewer
    Location:
    13q12.12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (23570412..23676093)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (22776896..22882553)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (24144551..24250232)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24066632-24067132 Neighboring gene uncharacterized LOC124903135 Neighboring gene NANOG hESC enhancer GRCh37_chr13:24081975-24082502 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:24100455-24101050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24141962-24142474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24142475-24142986 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5175 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32745 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:24192537-24193038 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:24195169-24195668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:24205756-24206564 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:24206565-24207373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24213321-24213822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24228053-24228554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7460 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:24269883-24270456 Neighboring gene uncharacterized LOC105370113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7462 Neighboring gene mitochondrial intermediate peptidase Neighboring gene MT-CO3 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance. Ding Z, et al. Neoplasia, 2020 Sep. PMID 32629176, Free PMC Article
    2. The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression. Shao L, et al. Genome Biol, 2019 May 24. PMID 31126313, Free PMC Article
    3. TROY expression is associated with pathological stage and poor prognosis in patients treated with radical cystectomy. Nomura M, et al. Cancer Biomark, 2019. PMID 30475756
    4. TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance. Loftus JC, et al. Mol Cancer Res, 2013 Aug. PMID 23699535, Free PMC Article
    5. Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target. Spanjaard RA, et al. Int J Cancer, 2007 Mar 15. PMID 17187358

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TNFRSF19 within the 13q12.12 Risk Locus Functions as a Lung Cancer Suppressor by Binding Wnt3a to Inhibit Wnt/beta-Catenin Signaling.
      Title: TNFRSF19 within the 13q12.12 Risk Locus Functions as a Lung Cancer Suppressor by Binding Wnt3a to Inhibit Wnt/β-Catenin Signaling.
    2. Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.
      Title: Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.
    3. Unique molecular characteristics of NAFLD-associated liver cancer accentuate beta-catenin/TNFRSF19-mediated immune evasion.
      Title: Unique molecular characteristics of NAFLD-associated liver cancer accentuate β-catenin/TNFRSF19-mediated immune evasion.
    4. Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
      Title: Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
    5. TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance.
      Title: TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance.
    6. Downregulation of TNFRSF19 and RAB43 by a novel miRNA, miR-HCC3, promotes proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cells.
      Title: Downregulation of TNFRSF19 and RAB43 by a novel miRNA, miR-HCC3, promotes proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cells.
    7. tumor marker tumor necrosis factor receptor superfamily member 19 as part of a four gene transcript score has prognostic value for metastatic-lethal progression in men treated for localized prostate cancer
      Title: A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies.
    8. Study showed that TNFRSF19 is highly expressed in nasopharyngeal carcinoma (NPC) and is required for cell proliferation and NPC development. TNFRSF19 was not involved in NFkappaB activation or associated with TRAF proteins. TbetaRI was identified as a specific binding partner for TNFRSF19. TNFRSF19 bound the kinase domain of TbetaRI in the cytoplasm, thereby blocking Smad2/3 association with TbetaRI and subsequent sign...
      Title: TNFRSF19 Inhibits TGFβ Signaling through Interaction with TGFβ Receptor Type I to Promote Tumorigenesis.
    9. three inherited variations at rs17336602 (G>C), rs4770489 (A>G), and rs34354770 (A>C) in 13q12.12 contribute to lung cancer risk and development by declining p53-responsive enhancer-mediated TNFRSF19 activation
      Title: The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression.
    10. TROY may therefore be a new molecular marker to aid in identifying and selecting patients undergoing radical cystectomy who could potentially benefit from multimodal treatment.
      Title: TROY expression is associated with pathological stage and poor prognosis in patients treated with radical cystectomy.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
    EBI GWAS Catalog
    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Novel associations for hypothyroidism include known autoimmune risk loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in hair follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 19
    Names
    toxicity and JNK inducer

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204458.3 → NP_001191387.1  tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001191387.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and the 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform (1). Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AY358888, BC047321, BF968836, BF971156, BM801444, DB223760
      Consensus CDS
      CCDS9301.1
      UniProtKB/Swiss-Prot
      Q9NS68
      Related
      ENSP00000371698.3, ENST00000382263.3
      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    2. NM_001204459.2 → NP_001191388.1  tumor necrosis factor receptor superfamily member 19 isoform 3

      See identical proteins and their annotated locations for NP_001191388.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in both UTR's and the 3' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK304290, AY358888, BC047321, BF968836, BF971156, BM801444, DA192370
      Consensus CDS
      CCDS55893.1
      UniProtKB/Swiss-Prot
      Q9NS68
      Related
      ENSP00000385408.2, ENST00000403372.6
      Conserved Domains (1) summary
      cl22855
      Location:1 → 17
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    3. NM_001354985.2 → NP_001341914.1  tumor necrosis factor receptor superfamily member 19 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL161422, AL354815
      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    4. NM_018647.5 → NP_061117.2  tumor necrosis factor receptor superfamily member 19 isoform 1 precursor

      See identical proteins and their annotated locations for NP_061117.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as TRADEbeta) encodes the longest isoform (1).
      Source sequence(s)
      AF167555, AL161422, BC047321, DB223760
      Consensus CDS
      CCDS9302.1
      UniProtKB/Swiss-Prot
      A8KA09, A8KA26, B1AM40, B1AM41, B4E2I6, Q9BXZ9, Q9BY00, Q9NS68, Q9NZV2
      Related
      ENSP00000371693.4, ENST00000382258.8
      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    5. NM_148957.4 → NP_683760.1  tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

      See identical proteins and their annotated locations for NP_683760.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as TRADEalpha) differs in both UTR's and the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform (1). Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AY358888, BC047321, BF968836, BF971156, BM801444, DA192370
      Consensus CDS
      CCDS9301.1
      UniProtKB/Swiss-Prot
      Q9NS68
      Related
      ENSP00000248484.4, ENST00000248484.9
      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      23570412..23676093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430440.1 → XP_047286396.1  tumor necrosis factor receptor superfamily member 19 isoform X1

    2. XM_047430442.1 → XP_047286398.1  tumor necrosis factor receptor superfamily member 19 isoform X2

    3. XM_005266446.3 → XP_005266503.1  tumor necrosis factor receptor superfamily member 19 isoform X2

      See identical proteins and their annotated locations for XP_005266503.1

      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    4. XM_047430441.1 → XP_047286397.1  tumor necrosis factor receptor superfamily member 19 isoform X1

    5. XM_047430443.1 → XP_047286399.1  tumor necrosis factor receptor superfamily member 19 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      22776896..22882553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374673.1 → XP_054230648.1  tumor necrosis factor receptor superfamily member 19 isoform X1

    2. XM_054374676.1 → XP_054230651.1  tumor necrosis factor receptor superfamily member 19 isoform X2

    3. XM_054374675.1 → XP_054230650.1  tumor necrosis factor receptor superfamily member 19 isoform X2

    4. XM_054374674.1 → XP_054230649.1  tumor necrosis factor receptor superfamily member 19 isoform X1

    5. XM_054374677.1 → XP_054230652.1  tumor necrosis factor receptor superfamily member 19 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NS68.1 GenPept UniProtKB/Swiss-Prot:Q9NS68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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