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    Strbp spermatid perinuclear RNA binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84476, updated on 2-May-2024

    Summary

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    Official Symbol
    Strbpprovided by RGD
    Official Full Name
    spermatid perinuclear RNA binding proteinprovided by RGD
    Primary source
    RGD:620673
    See related
    Ensembl:ENSRNOG00000010150 AllianceGenome:RGD:620673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spnr
    Summary
    Predicted to enable double-stranded RNA binding activity; microtubule binding activity; and single-stranded RNA binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to act upstream of or within mechanosensory behavior and spermatid development. Predicted to be located in manchette and nucleus. Orthologous to human STRBP (spermatid perinuclear RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 261.2), Adrenal (RPKM 148.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Strbp in Genome Data Viewer
    Location:
    3q11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41738096..41879054, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21328310..21467753, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21817680..21956988, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350365 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene RAB GTPase activating protein 1 Neighboring gene G protein-coupled receptor 21 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134486087 Neighboring gene ribosomal protein S16 like 1 Neighboring gene uncharacterized LOC120101537

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. Pires-daSilva A, et al. Dev Biol, 2001 May 15. PMID 11336498
    2. Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. Schumacher JM, et al. J Cell Biol, 1995 May. PMID 7744952, Free PMC Article
    3. A new double-stranded RNA-binding protein that interacts with PKR. Coolidge CJ, et al. Nucleic Acids Res, 2000 Mar 15. PMID 10684936, Free PMC Article
    4. Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Schumacher JM, et al. Biol Reprod, 1998 Jul. PMID 9674995
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mechanosensory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mechanosensory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spermatid perinuclear RNA-binding protein
    Names
    74 kDa double-stranded RNA-binding protein
    double-stranded RNA-binding protein p74
    p74

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429552.1 → NP_001416481.1  spermatid perinuclear RNA-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001429553.1 → NP_001416482.1  spermatid perinuclear RNA-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001429554.1 → NP_001416483.1  spermatid perinuclear RNA-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_053416.3 → NP_445868.2  spermatid perinuclear RNA-binding protein

      See identical proteins and their annotated locations for NP_445868.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9JKU6
      UniProtKB/TrEMBL
      A6JET9, D3ZDD7
      Related
      ENSRNOP00000062543.1, ENSRNOT00000066377.3
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      41738096..41879054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284719.1 → XP_063140789.1  spermatid perinuclear RNA-binding protein isoform X3

    2. XM_039105987.2 → XP_038961915.1  spermatid perinuclear RNA-binding protein isoform X7

      Conserved Domains (4) summary
      cl02675
      Location:8 → 63
      DZF; DZF domain
      pfam17228
      Location:337 → 393
      SGP; Sulphur globule protein
      cd19909
      Location:113 → 196
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:241 → 304
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    3. XM_039105986.2 → XP_038961914.1  spermatid perinuclear RNA-binding protein isoform X6

      Conserved Domains (4) summary
      cl02675
      Location:1 → 153
      DZF; DZF domain
      pfam17228
      Location:427 → 483
      SGP; Sulphur globule protein
      cd19909
      Location:203 → 286
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:331 → 394
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    4. XM_063284728.1 → XP_063140798.1  spermatid perinuclear RNA-binding protein isoform X6

    5. XM_063284717.1 → XP_063140787.1  spermatid perinuclear RNA-binding protein isoform X1

    6. XM_063284712.1 → XP_063140782.1  spermatid perinuclear RNA-binding protein isoform X1

    7. XM_063284714.1 → XP_063140784.1  spermatid perinuclear RNA-binding protein isoform X1

    8. XM_063284711.1 → XP_063140781.1  spermatid perinuclear RNA-binding protein isoform X1

    9. XM_063284715.1 → XP_063140785.1  spermatid perinuclear RNA-binding protein isoform X1

    10. XM_063284713.1 → XP_063140783.1  spermatid perinuclear RNA-binding protein isoform X1

    11. XM_063284716.1 → XP_063140786.1  spermatid perinuclear RNA-binding protein isoform X1

    12. XM_063284721.1 → XP_063140791.1  spermatid perinuclear RNA-binding protein isoform X4

    13. XM_063284720.1 → XP_063140790.1  spermatid perinuclear RNA-binding protein isoform X4

    14. XM_063284722.1 → XP_063140792.1  spermatid perinuclear RNA-binding protein isoform X4

    15. XM_039105982.2 → XP_038961910.1  spermatid perinuclear RNA-binding protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2K3L7
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    16. XM_039105984.2 → XP_038961912.1  spermatid perinuclear RNA-binding protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2K3L7
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    17. XM_039105985.2 → XP_038961913.1  spermatid perinuclear RNA-binding protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2K3L7
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 664
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    18. XM_063284727.1 → XP_063140797.1  spermatid perinuclear RNA-binding protein isoform X5

      UniProtKB/TrEMBL
      A6JET9, D3ZDD7

    19. XM_063284725.1 → XP_063140795.1  spermatid perinuclear RNA-binding protein isoform X5

      UniProtKB/TrEMBL
      A6JET9, D3ZDD7

    20. XM_063284726.1 → XP_063140796.1  spermatid perinuclear RNA-binding protein isoform X5

      UniProtKB/TrEMBL
      A6JET9, D3ZDD7

    21. XM_008761777.4 → XP_008759999.1  spermatid perinuclear RNA-binding protein isoform X5

      UniProtKB/Swiss-Prot
      Q9JKU6
      UniProtKB/TrEMBL
      A6JET9, D3ZDD7
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    22. XM_063284718.1 → XP_063140788.1  spermatid perinuclear RNA-binding protein isoform X2

    23. XM_063284724.1 → XP_063140794.1  spermatid perinuclear RNA-binding protein isoform X5

      UniProtKB/TrEMBL
      A6JET9, D3ZDD7

    24. XM_063284723.1 → XP_063140793.1  spermatid perinuclear RNA-binding protein isoform X5

      UniProtKB/TrEMBL
      A6JET9, D3ZDD7

    RNA

    1. XR_591457.4 RNA Sequence

    2. XR_010064705.1 RNA Sequence

    3. XR_010064704.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKU6.1 GenPept UniProtKB/Swiss-Prot:Q9JKU6

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