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    Asb13 ankyrin repeat and SOCS box-containing 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361268, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Asb13provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 13provided by RGD
    Primary source
    RGD:1310387
    See related
    Ensembl:ENSRNOG00000017967 AllianceGenome:RGD:1310387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB13 (ankyrin repeat and SOCS box containing 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 246.8), Testes (RPKM 221.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb13 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71474531..71493238, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66564653..66583365, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (70215401..70234103, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene nucleolar pre-rRNA processing protein NIP7, pseudogene 15 Neighboring gene ribosomal protein L29, pseudogene 3 Neighboring gene uncharacterized LOC134482597 Neighboring gene transcription activation suppressor family member 2 Neighboring gene GDP dissociation inhibitor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108420.1 → NP_001101890.1  ankyrin repeat and SOCS box protein 13

      See identical proteins and their annotated locations for NP_001101890.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5ZVB3, A6JLQ6, D3ZEJ6
      Related
      ENSRNOP00000024200.2, ENSRNOT00000024200.4
      Conserved Domains (5) summary
      cd00204
      Location:46 → 170
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03729
      Location:237 → 278
      SOCS_ASB13; SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
      pfam12796
      Location:56 → 147
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:19 → 72
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:119 → 147
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      71474531..71493238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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