NPR4 NPR1-like protein 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: NPR4
Gene description: NPR1-like protein 4
Primary source: Araport:AT4G19660
Locus tag: AT4G19660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATNPR4; NPR1-like protein 4; T16H5.20; T16H5_20
Summary: Encodes NPR4, a ankyrin repeat BTB/POZ domain-containing protein with 36% sequence identity with NPR1. Mutants are more susceptible to the bacterial pathogen Pseudomonas syringe pv. tomato DC3000 and to the fungal pathogen Erysiphe cichoracearum, but do not differ markedly from wild type in interaction with virulent and avirulent strains of the oomycete Peronospora parasitica. NPR4 is required for basal defense against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. NPR3 and NPR4 are receptors for the immune signal salicylic acid.
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Genomic context

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See NPR4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (10696266..10698811, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diverse Roles of the Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Plant Immunity.
Title: Diverse Roles of the Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Plant Immunity.
Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
Title: Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
The expression, purification, crystallization and crystallographic analysis of Arabidopsis thaliana NPR4 protein have been reported.
Title: AtNPR4 from Arabidopsis thaliana: expression, purification, crystallization and crystallographic analysis.
both NPR1 and NPR3/NPR4 are bona fide salicylic acid receptors, but play opposite roles in transcriptional regulation of salicylic acid-induced defense gene expression
Title: Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity.
Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway
Title: Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway.
the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind salicylic acid with different affinities
Title: NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants.
The role of NPR1, NPR3, and NPR4 in the disease resistance of A. thaliana are reported.
Title: Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001341366.1

Supported by ESTs:

NM_118086.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables salicylic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of jasmonic acid mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of jasmonic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of salicylic acid mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of salicylic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in systemic acquired resistance, salicylic acid mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NPR1-like protein 4

NP_193701.2

NPR1-like protein 4 (NPR4); CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), NPR1/NIM1 like, C-terminal (InterPro:IPR021094), BTB/POZ fold (InterPro:IPR011333), Ankyrin repeat-containing domain (InterPro:IPR020683), BTB/POZ-like (InterPro:IPR000210), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: NPR1-like protein 3 (TAIR:AT5G45110.1); Has 1751 Blast hits to 1617 proteins in 183 species: Archae - 0; Bacteria - 140; Metazoa - 493; Fungi - 63; Plants - 647; Viruses - 2; Other Eukaryotes - 406 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

10696266..10698811 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118086.3 → NP_193701.2 NPR1-like protein 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193701.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O81848, Q5ICL9

UniProtKB/TrEMBL

A0A178UZK3

Conserved Domains (7) summary

pfam11900
Location:215 → 258

DUF3420; Domain of unknown function (DUF3420)

smart00225
Location:55 → 179

BTB; Broad-Complex, Tramtrack and Bric a brac

cd00204
Location:260 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12313
Location:357 → 551

NPR1_like_C; NPR1/NIM1 like defence protein C terminal

pfam13857
Location:302 → 355

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:284 → 313

ANK; ANK repeat [structural motif]

cl02518
Location:42 → 133

BTB; BTB/POZ domain
NM_001341366.1 → NP_001328027.1 NPR1-like protein 4 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B3C8, A0A654FQW9

Conserved Domains (7) summary

pfam11900
Location:215 → 258

DUF3420; Domain of unknown function (DUF3420)

smart00225
Location:55 → 179

BTB; Broad-Complex, Tramtrack and Bric a brac

cd00204
Location:260 → 352

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12313
Location:357 → 578

NPR1_like_C; NPR1/NIM1 like defence protein C terminal

pfam13857
Location:302 → 355

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:284 → 313

ANK; ANK repeat [structural motif]

cl02518
Location:42 → 133

BTB; BTB/POZ domain