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    AT4G19530 disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827695, updated on 15-Feb-2024

    Summary

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    Gene symbol
    AT4G19530
    Gene description
    disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    Araport:AT4G19530
    Locus tag
    AT4G19530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24J7.90; F24J7_90
    Summary
    Encodes a TIR-NB-LRR resistance protein. Transient expression in tobacco induces cell death.
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    Genomic context

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    See AT4G19530 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (10651744..10657282)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Disease resistance protein (TIR-NBS-LRR class) Neighboring gene disease resistance protein (TIR-NBS-LRR class) family Neighboring gene zinc ion binding / transcription regulator Neighboring gene INDH1(iron-sulfur protein required for NADH dehydrogenase) Neighboring gene Cyclin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction. Swiderski MR, et al. Mol Plant Microbe Interact, 2009 Feb. PMID 19132868
    2. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. Yoo H, et al. Mol Plant, 2020 Jan 6. PMID 31568832, Free PMC Article
    3. Identification and dynamics of Arabidopsis adaptor protein-2 complex and its involvement in floral organ development. Yamaoka S, et al. Plant Cell, 2013 Aug. PMID 23975897, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118073.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response-activating signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    disease resistance protein (TIR-NBS-LRR class) family
    NP_193688.1
    • disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: defense response signaling pathway, resistance gene-dependent, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G45250.1); Has 17572 Blast hits to 11989 proteins in 539 species: Archae - 6; Bacteria - 936; Metazoa - 1722; Fungi - 81; Plants - 14067; Viruses - 2; Other Eukaryotes - 758 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10651744..10657282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341356.1 → NP_001328514.1  disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4W0, O49471
      UniProtKB/TrEMBL
      A0A5S9XU29, A0A654FRB5
      Conserved Domains (2) summary
      PLN03210
      Location:15 → 1125
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:714 → 735
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_118073.2 → NP_193688.1  disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FRB5
      Conserved Domains (3) summary
      PLN03210
      Location:15 → 1103
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:714 → 735
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:15 → 178
      TIR; TIR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49471.2

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