Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd17b13provided by RGD
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 13provided by RGD
Primary source: RGD:1359553
See related: Ensembl:ENSRNOG00000002212 AllianceGenome:RGD:1359553
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Predicted to act upstream of or within positive regulation of lipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. Orthologous to human HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1223.0) See more
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Genomic context

Location:: 14p22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (6056708..6071463)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (5751697..5766809)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (7113544..7128218)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables steroid dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 17-beta-hydroxysteroid dehydrogenase 13

Names: 17-beta-HSD 13; hepatic retinol/retinal dehydrogenase; short-chain dehydrogenase/reductase 9

NP_001009684.1

EC 1.1.1.105

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009684.1 → NP_001009684.1 17-beta-hydroxysteroid dehydrogenase 13 precursor

See identical proteins and their annotated locations for NP_001009684.1

Status: PROVISIONAL

Source sequence(s)

BC088191

UniProtKB/Swiss-Prot

Q5M875

UniProtKB/TrEMBL

A0A8I5ZU34

Related

ENSRNOP00000029333.2, ENSRNOT00000038188.3

Conserved Domains (2) summary

cd05339
Location:38 → 277

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

pfam00106
Location:37 → 228

adh_short; short chain dehydrogenase