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    Sass6 SAS-6 centriolar assembly protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310807, updated on 13-Apr-2024

    Summary

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    Symbol
    Sass6provided by RGD
    Full Name
    SAS-6 centriolar assembly proteinprovided by RGD
    Primary source
    RGD:1306255
    See related
    Ensembl:ENSRNOG00000015211 AllianceGenome:RGD:1306255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306255
    Summary
    Predicted to be involved in centriole replication. Predicted to be located in cytosol; deuterosome; and microtubule organizing center. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 14. Orthologous to human SASS6 (SAS-6 centriolar assembly protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 81.9), Spleen (RPKM 51.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sass6 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (207231896..207263840)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204546660..204578930)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219626851..219660975)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene dihydrolipoamide branched chain transacylase E2 Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13 homolog Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene uncharacterized LOC102548510 Neighboring gene solute carrier family 35 member A3 Neighboring gene amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nucleoporin Nup62 maintains centrosome homeostasis. Hashizume C, et al. Cell Cycle, 2013 Dec 15. PMID 24107630, Free PMC Article
    2. The Polo kinase Plk4 functions in centriole duplication. Habedanck R, et al. Nat Cell Biol, 2005 Nov. PMID 16244668
    3. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Leidel S, et al. Nat Cell Biol, 2005 Feb. PMID 15665853
    4. Deuterosome-mediated centriole biogenesis. Klos Dehring DA, et al. Dev Cell, 2013 Oct 14. PMID 24075808, Free PMC Article
    5. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. Tang CJ, et al. EMBO J, 2011 Oct 21. PMID 22020124, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in deuterosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procentriole replication complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spindle assembly abnormal protein 6 homolog
    Names
    spindle assembly 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415058.1 → NP_001401987.1  spindle assembly abnormal protein 6 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GMD5, A6HVA1
      Related
      ENSRNOP00000097084.1, ENSRNOT00000112539.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      207231896..207263840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281937.1 → XP_063138007.1  spindle assembly abnormal protein 6 homolog isoform X1

    2. XM_063281938.1 → XP_063138008.1  spindle assembly abnormal protein 6 homolog isoform X2

      UniProtKB/TrEMBL
      D3ZVI7

    3. XM_006233228.4 → XP_006233290.1  spindle assembly abnormal protein 6 homolog isoform X3

      UniProtKB/TrEMBL
      A6HVA3
      Related
      ENSRNOP00000063437.3
      Conserved Domains (3) summary
      cd00187
      Location:360 → 480
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      pfam16531
      Location:46 → 140
      SAS-6_N; Centriolar protein SAS N-terminal
      cl21455
      Location:56 → 348
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_063281939.1 → XP_063138009.1  spindle assembly abnormal protein 6 homolog isoform X4

    5. XM_039102429.2 → XP_038958357.1  spindle assembly abnormal protein 6 homolog isoform X5

      UniProtKB/TrEMBL
      A6HVA2
      Conserved Domains (2) summary
      TIGR02168
      Location:165 → 464
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd10142
      Location:4 → 144
      HD_SAS6_N; N-terminal head domain found in spindle assembly abnormal protein 6 and similar proteins

    6. XM_063281940.1 → XP_063138010.1  spindle assembly abnormal protein 6 homolog isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107719.1: Suppressed sequence

      Description
      NM_001107719.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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