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    Zfp446 zinc finger protein 446 [ Mus musculus (house mouse) ]

    Gene ID: 269870, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Zfp446provided by MGI
    Official Full Name
    zinc finger protein 446provided by MGI
    Primary source
    MGI:MGI:2442185
    See related
    Ensembl:ENSMUSG00000033961 AllianceGenome:MGI:2442185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930031C22; A630035I11Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in early conceptus; genitourinary system; and limb. Orthologous to human ZNF446 (zinc finger protein 446). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 2.1), CNS E14 (RPKM 2.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp446 in Genome Data Viewer
    Location:
    7 A1; 7 7.71 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12711726..12718323)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12976196..12985717)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810019N24 gene Neighboring gene STARR-seq mESC enhancer starr_18063 Neighboring gene predicted gene 29638 Neighboring gene zinc finger protein 324 Neighboring gene solute carrier family 27 (fatty acid transporter), member 5 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13594963-13595072 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13595132-13595322 Neighboring gene STARR-positive B cell enhancer ABC_E6511

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 446

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168561.2 → NP_001162033.1  zinc finger protein 446 isoform 2

      See identical proteins and their annotated locations for NP_001162033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS52023.1
      UniProtKB/TrEMBL
      Q149D4
      Related
      ENSMUSP00000104177.2, ENSMUST00000108537.8
      Conserved Domains (4) summary
      smart00431
      Location:22 → 127
      SCAN; leucine rich region
      sd00017
      Location:246 → 266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:136 → 162
      KRAB; KRAB box
      pfam02023
      Location:22 → 110
      SCAN; SCAN domain

    2. NM_001168562.2 → NP_001162034.1  zinc finger protein 446 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate segment in the 3' portion of the coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS52022.1
      UniProtKB/TrEMBL
      E9Q6F9, Q149D5
      Related
      ENSMUSP00000104175.2, ENSMUST00000108535.8
      Conserved Domains (3) summary
      smart00431
      Location:22 → 126
      SCAN; leucine rich region
      pfam01352
      Location:211 → 237
      KRAB; KRAB box
      pfam02023
      Location:22 → 110
      SCAN; SCAN domain

    3. NM_001404125.1 → NP_001391054.1  zinc finger protein 446 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121301
      UniProtKB/TrEMBL
      G3X9U2
      Related
      ENSMUSP00000104176.2, ENSMUST00000108536.3

    4. NM_001404126.1 → NP_001391055.1  zinc finger protein 446 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121301

    5. NM_001404127.1 → NP_001391056.1  zinc finger protein 446 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121301

    6. NM_175558.5 → NP_780767.1  zinc finger protein 446 isoform 1

      See identical proteins and their annotated locations for NP_780767.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS20820.1
      UniProtKB/TrEMBL
      Q80Y64, Q8C9M8
      Related
      ENSMUSP00000039073.8, ENSMUST00000045810.15
      Conserved Domains (5) summary
      smart00431
      Location:122 → 226
      SCAN; leucine rich region
      cd07765
      Location:301 → 338
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00355
      Location:468 → 490
      ZnF_C2H2; zinc finger
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:122 → 210
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12711726..12718323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004934108.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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