ITPR3 inositol 1,4,5-trisphosphate receptor type 3 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ITPR3provided by VGNC
Official Full Name: inositol 1,4,5-trisphosphate receptor type 3provided by VGNC
Primary source: VGNC:VGNC:30348
See related: BGD:BT13799; Ensembl:ENSBTAG00000013245
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 58

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (7745549..7813182)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role in cillary movement, coupled with chromogranin A
Title: Colocalization of chromogranin A and inositol 1,4,5-trisphosphate receptor in ciliated cells of the bovine oviduct.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate receptor type 3

Names: IP3 receptor; IP3R 3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; killer cell lectin-like receptor subfamily G member 2; type 3 InsP3 receptor; type 3 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174370.3 → NP_776795.1 inositol 1,4,5-trisphosphate receptor type 3

See identical proteins and their annotated locations for NP_776795.1

Status: PROVISIONAL

Source sequence(s)

AF402601

UniProtKB/Swiss-Prot

Q8WN95

UniProtKB/TrEMBL

A0A3Q1LW35

Related

ENSBTAP00000047648.3, ENSBTAT00000053490.4

Conserved Domains (7) summary

smart00472
Location:232 → 288

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2267 → 2521

Ion_trans; Ion transport protein

pfam01365
Location:475 → 665

RYDR_ITPR; RIH domain

pfam02815
Location:234 → 432

MIR; MIR domain

pfam08454
Location:1862 → 1967

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:3 → 226

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

pfam12730
Location:2194 → 2325

ABC2_membrane_4; ABC-2 family transporter protein