Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csf2rb2provided by MGI
Official Full Name: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)provided by MGI
Primary source: MGI:MGI:1339760
See related: Ensembl:ENSMUSG00000071714 AllianceGenome:MGI:1339760
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bil3; Il3r; AIC2A; Il3rb; Il3rb2; BetaIl3; Csfgmrb
Summary: Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Located in plasma membrane. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RB (colony stimulating factor 2 receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 26.5), spleen adult (RPKM 9.9) and 15 other tissues See more
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Genomic context

Location:: 15 E1; 15 37.22 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78166707..78189921, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (78282507..78305721, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The beta chain cytokine receptor Csf2rb2 was identified as a downstream molecule of Notch signaling in hematopoietic cells.
Title: Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.
Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications.
Title: Identification of potential biomarkers for post-traumatic complications released after trauma-hemorrhage from murine Kupffer cells and its investigation in lung and liver.
this receptor adopts an arch-like intertwined homodimeric structure
Title: Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation.
the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling
Title: The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.
Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms.
Title: Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.
Bcr-Abl oncoprotein requires the IL-3 receptor/Jak2/Stat5 pathways for oncogenic transformation of NIH 3T3 fibroblasts.
Title: BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor.
IL-3-driven survival and proliferation is negatively regulated, potentially via tyrosine phosphorylation of Aic2A and STAT5
Title: Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csf2rb2 (e-PCR), detects polymorphism
- UniSTS:265217

M34397 (e-PCR)
- UniSTS:180792

Csf2rb2 (e-PCR), detects polymorphism
- UniSTS:141414

Csf2rb2 (e-PCR), detects polymorphism
- UniSTS:141415

Csf2rb (e-PCR), detects polymorphism
- UniSTS:265070

D1S3690 (e-PCR)
- UniSTS:474268

M29855 (e-PCR)
- UniSTS:160479

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of granulocyte macrophage colony-stimulating factor receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-3 receptor class 2 subunit beta

Names: IL-3 receptor class 2 subunit beta; IL-3R class 2 subunit beta; colony-stimulating factor 2 receptor subunit beta-2; interleukin-3 receptor class II beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287389.1 → NP_001274318.1 interleukin-3 receptor class 2 subunit beta isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AK155626, AL589692, BY208313

Consensus CDS

CCDS88799.1

UniProtKB/TrEMBL

A0A2R8VHE8, Q3U1Z1

Related

ENSMUSP00000155013.3, ENSMUST00000230115.3

Conserved Domains (2) summary

cd00063
Location:245 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:140 → 218

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_007781.3 → NP_031807.1 interleukin-3 receptor class 2 subunit beta isoform 1 precursor

See identical proteins and their annotated locations for NP_031807.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AL589692

Consensus CDS

CCDS27611.1

UniProtKB/Swiss-Prot

P26954

UniProtKB/TrEMBL

Q3U241

Related

ENSMUSP00000094083.4, ENSMUST00000096356.5

Conserved Domains (3) summary

smart00060
Location:137 → 225

FN3; Fibronectin type 3 domain

cd00063
Location:354 → 438

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:249 → 327

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...