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    Lpar5 lysophosphatidic acid receptor 5 [ Mus musculus (house mouse) ]

    Gene ID: 381810, updated on 12-May-2024

    Summary

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    Official Symbol
    Lpar5provided by MGI
    Official Full Name
    lysophosphatidic acid receptor 5provided by MGI
    Primary source
    MGI:MGI:2685918
    See related
    Ensembl:ENSMUSG00000067714 AllianceGenome:MGI:2685918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LPA5; GPR93; Gpr92; Gm1072
    Summary
    Predicted to enable G protein-coupled receptor activity. Acts upstream of or within behavioral response to pain and positive regulation of CREB transcription factor activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including future brain; gut; immune system; liver; and nervous system. Orthologous to human LPAR5 (lysophosphatidic acid receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in small intestine adult (RPKM 19.8), duodenum adult (RPKM 18.6) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lpar5 in Genome Data Viewer
    Location:
    6 F2; 6 59.21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125044808..125063092)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125067844..125086129)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4 Neighboring gene proacrosin binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125039823-125040010 Neighboring gene STARR-positive B cell enhancer ABC_E4864 Neighboring gene microRNA 7045 Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene predicted gene, 23751

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model. de Souza CO, et al. J Clin Invest, 2022 Nov 1. PMID 36066975, Free PMC Article
    2. Lysophosphatidic Acid Receptor 5 (LPA(5)) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro. Joshi L, et al. Cells, 2022 Mar 22. PMID 35406635, Free PMC Article
    3. Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages. Gaire BP, et al. Cells, 2020 Jul 22. PMID 32707926, Free PMC Article
    4. Lysophosphatidic Acid Receptor 5 Plays a Pathogenic Role in Brain Damage after Focal Cerebral Ischemia by Modulating Neuroinflammatory Responses. Sapkota A, et al. Cells, 2020 Jun 10. PMID 32532027, Free PMC Article
    5. Expression of lysophosphatidic acid receptor 5 is necessary for the regulation of intestinal Na(+)/H(+) exchanger 3 by lysophosphatidic acid in vivo. Jenkin KA, et al. Am J Physiol Gastrointest Liver Physiol, 2018 Oct 1. PMID 29792531, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling.
      Title: Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling.
    2. Lysophosphatidic Acid Receptor 5 (LPA5) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro.
      Title: Lysophosphatidic Acid Receptor 5 (LPA(5)) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro.
    3. Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
      Title: Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
    4. Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model.
      Title: Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model.
    5. Lysophosphatidic Acid Receptor 5 Plays a Pathogenic Role in Brain Damage after Focal Cerebral Ischemia by Modulating Neuroinflammatory Responses.
      Title: Lysophosphatidic Acid Receptor 5 Plays a Pathogenic Role in Brain Damage after Focal Cerebral Ischemia by Modulating Neuroinflammatory Responses.
    6. Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages.
      Title: Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages.
    7. LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
      Title: LPA(5) Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
    8. Lysophosphatidic acid did not activate NHE3 or fluid absorption in Lpar5 deficient mice.
      Title: Expression of lysophosphatidic acid receptor 5 is necessary for the regulation of intestinal Na(+)/H(+) exchanger 3 by lysophosphatidic acid in vivo.
    9. These observations suggest that dietary lipid-induced ApoA-IV is associated with Cck synthesis in the duodenum and that ApoA-IV protein directly enhances CCK release through the activation of a LPAR5-dependent pathway.
      Title: Apolipoprotein A-IV enhances cholecystokinnin secretion.
    10. Findings suggest that lysophosphatidic acid receptor 5 antagonists elicit broad analgesic effects against both neuropathic and inflammatory pain.
      Title: Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavioral response to pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within behavioral response to pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of CREB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of CREB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 5
    Names
    G protein-coupled receptor 92
    LPA receptor 5
    LPA-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163268.2 → NP_001156740.2  lysophosphatidic acid receptor 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC134529
      UniProtKB/Swiss-Prot
      Q149R9, Q3V2G2, Q80T30
      Related
      ENSMUSP00000119904.4, ENSMUST00000140346.10
      Conserved Domains (2) summary
      cd14964
      Location:29 → 53
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:27 → 312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001163269.2 → NP_001156741.2  lysophosphatidic acid receptor 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC134529
      UniProtKB/Swiss-Prot
      Q149R9, Q3V2G2, Q80T30
      Related
      ENSMUSP00000085630.7, ENSMUST00000088292.7
      Conserved Domains (2) summary
      cd14964
      Location:29 → 53
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:27 → 312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125044808..125063092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506340.5 → XP_006506403.1  lysophosphatidic acid receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006506403.1

      UniProtKB/TrEMBL
      G3X9K0
      Conserved Domains (2) summary
      cd14964
      Location:41 → 65
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:39 → 324
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q149R9.2 GenPept UniProtKB/Swiss-Prot:Q149R9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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