LIN28B-AS1 LIN28B antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LIN28B-AS1provided by HGNC
Official Full Name: LIN28B antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:21553
See related: Ensembl:ENSG00000203809 AllianceGenome:HGNC:21553
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C6orf220; LINC00577; dJ439I14.1
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6q16.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (104936294..104940527, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (106112313..106116542, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (105384169..105388402, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIN28B-AS1-IGF2BP1 binding promotes hepatocellular carcinoma cell progression.
Title: LIN28B-AS1-IGF2BP1 binding promotes hepatocellular carcinoma cell progression.
Study provides evidence that LIN28B-AS1 was the first functional cancer-testis (CT)-lncRNA in cancer and comprises a regulation network with CT protein IGF2BP1 and LIN28B in the carcinogenesis of lung adenocarcinoma (LUAD). LIN28B-AS1 regulates LIN28B expression and promotes proliferation and metastasis in LUAD cells by interacting with IGF2BP1.
Title: A cancer-testis non-coding RNA LIN28B-AS1 activates driver gene LIN28B by interacting with IGF2BP1 in lung adenocarcinoma.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

long intergenic non-protein coding RNA 577

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.