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    Prss30 protease, serine, 30 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287106, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Prss30provided by RGD
    Official Full Name
    protease, serine, 30provided by RGD
    Primary source
    RGD:735142
    See related
    Ensembl:ENSRNOG00000033266 AllianceGenome:RGD:735142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    tmsp-1; Tmprss8
    Summary
    Enables serine-type endopeptidase activity and sodium channel regulator activity. Involved in proteolysis and sodium ion transport. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 54.5), Uterus (RPKM 18.3) and 1 other tissue See more
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    Genomic context

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    See Prss30 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13511916..13519968, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13007341..13014827, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13348289..13355833, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene uncharacterized LOC120095045 Neighboring gene zymogen granule protein 16B Neighboring gene serine protease 22 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator. Okumura Y, et al. Biol Chem, 2003 Oct-Nov. PMID 14669991
    2. Characterisation of a novel murine intestinal serine protease, DISP. Shaw-Smith CJ, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786627
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease 30
    Names
    distal intestinal serine protease
    transmembrane protease, serine 8 (intestinal)
    transmembrane serine protease 1
    transmembrane serine protease 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199371.2 → NP_955403.2  serine protease 30 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P83748
      Related
      ENSRNOP00000037368.5, ENSRNOT00000034340.6
      Conserved Domains (1) summary
      cd00190
      Location:31 → 269
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13511916..13519968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245923.5 → XP_006245985.1  serine protease 30 isoform X1

      See identical proteins and their annotated locations for XP_006245985.1

      UniProtKB/Swiss-Prot
      P83748
      Conserved Domains (1) summary
      cd00190
      Location:31 → 269
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_063268554.1 → XP_063124624.1  serine protease 30 isoform X2

      UniProtKB/TrEMBL
      A6HCP4, F1LQU8

    3. XM_063268555.1 → XP_063124625.1  serine protease 30 isoform X2

      UniProtKB/TrEMBL
      A6HCP4, F1LQU8

    4. XM_063268553.1 → XP_063124623.1  serine protease 30 isoform X1

      UniProtKB/Swiss-Prot
      P83748

    5. XM_063268551.1 → XP_063124621.1  serine protease 30 isoform X1

      UniProtKB/Swiss-Prot
      P83748
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83748.1 GenPept UniProtKB/Swiss-Prot:P83748

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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