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    Dapk2 death-associated protein kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300799, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dapk2provided by RGD
    Official Full Name
    death-associated protein kinase 2provided by RGD
    Primary source
    RGD:1304708
    See related
    Ensembl:ENSRNOG00000017332 AllianceGenome:RGD:1304708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including anoikis; positive regulation of granulocyte chemotaxis; and regulation of apoptotic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and nucleus. Orthologous to human DAPK2 (death associated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 88.9), Muscle (RPKM 63.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dapk2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75601621..75720619)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66706536..66825567)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71822107..71941941)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 1 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene uncharacterized LOC108351731 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene uncharacterized LOC134480197

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2. Li S, et al. J Hum Genet, 2015 Nov. PMID 26334104
    2. Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. Li H, et al. J Biol Chem, 2009 Jan 23. PMID 18957423
    3. Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. Shani G, et al. EMBO J, 2001 Mar 1. PMID 11230133, Free PMC Article
    4. DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. Geering B, et al. J Leukoc Biol, 2014 Feb. PMID 24163421
    5. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Kawai T, et al. Oncogene, 1999 Jun 10. PMID 10376525

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
      Title: CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
    2. MiR-133a overexpression may inhibit I/R injury-mediated cardiomyocyte apoptosis by targeting DAPK2, leading to reduced DAPK2 protein.
      Title: Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109553

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anoikis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of eosinophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    death-associated protein kinase 2
    Names
    death-associated kinase 2
    NP_001013127.1
    NP_001382664.1
    XP_008764463.1
    XP_038937050.1
    XP_038937053.1
    XP_038937054.1
    XP_063121234.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013109.1 → NP_001013127.1  death-associated protein kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_001013127.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091410
      UniProtKB/TrEMBL
      F1LS59, Q5BJN2
      Conserved Domains (2) summary
      smart00220
      Location:2 → 130
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 130
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001395735.1 → NP_001382664.1  death-associated protein kinase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2JX07, A6J5H8
      Related
      ENSRNOP00000070087.2, ENSRNOT00000089147.2
      Conserved Domains (1) summary
      cd14196
      Location:12 → 280
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75601621..75720619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081122.2 → XP_038937050.1  death-associated protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GD46
      Conserved Domains (2) summary
      TIGR02168
      Location:272 → 369
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl21453
      Location:12 → 203
      PKc_like; Protein Kinases, catalytic domain

    2. XM_008766241.4 → XP_008764463.1  death-associated protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GD46
      Related
      ENSRNOP00000085631.1
      Conserved Domains (2) summary
      smart00220
      Location:18 → 280
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14196
      Location:12 → 280
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

    3. XM_063265164.1 → XP_063121234.1  death-associated protein kinase 2 isoform X4

    4. XM_039081125.2 → XP_038937053.1  death-associated protein kinase 2 isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:199 → 291
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl21453
      Location:1 → 130
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039081126.2 → XP_038937054.1  death-associated protein kinase 2 isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:199 → 291
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl21453
      Location:1 → 130
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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