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    Mtus1 microtubule associated scaffold protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306487, updated on 30-Mar-2024

    Summary

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    Symbol
    Mtus1provided by RGD
    Full Name
    microtubule associated scaffold protein 1provided by RGD
    Primary source
    RGD:631381
    See related
    Ensembl:ENSRNOG00000010748 AllianceGenome:RGD:631381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ATIP4; Mtsg1; Atip3b
    Summary
    Predicted to enable microtubule binding activity. Involved in cellular response to angiotensin. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 617.5), Adrenal (RPKM 314.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtus1 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (57905991..58051466)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51202497..51347794)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54240892..54386131)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene pericentriolar material 1 Neighboring gene fibrinogen-like 1 Neighboring gene uncharacterized LOC103693968 Neighboring gene uncharacterized LOC120097427 Neighboring gene uncharacterized LOC120097428 Neighboring gene platelet-derived growth factor receptor-like Neighboring gene elongin B, pseduogene 1 Neighboring gene solute carrier family 7 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2. Varghayee N, et al. J Renin Angiotensin Aldosterone Syst, 2015 Mar. PMID 23559668
    2. Gene sequencing and tissue expression of unknown isoforms of an angiotensin II type 2 receptor interacting protein, ATIP, in the rat. Krezel MA, et al. Biosci Biotechnol Biochem, 2011. PMID 21389599
    3. Loss of MTUS1 Expression Is Associated With Poor Prognosis in Patients With Gallbladder Carcinoma. Sim J, et al. In Vivo, 2020 Jan-Feb. PMID 31882471, Free PMC Article
    4. MTUS1/ATIP3a down-regulation is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma. Zhao T, et al. BMC Cancer, 2015 Mar 31. PMID 25885343, Free PMC Article
    5. Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization. Jing F, et al. PLoS One, 2013. PMID 23565185, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first report to identify that ATIP may have a similar role in other disease states characterised by excessive growth
      Title: Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2.
    2. Expression levels of isoformes ATIP3 and ATIP4 in rat tissues were examined. There was little similarity in the relative tissue distribution of the various ATIP isoforms in rat and human
      Title: Gene sequencing and tissue expression of unknown isoforms of an angiotensin II type 2 receptor interacting protein, ATIP, in the rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to angiotensin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated tumor suppressor 1 homolog
    Names
    angiotensin-II type 2 receptor-interacting protein
    growth factor inhibitor
    microtubule associated tumor suppressor 1
    mitochondrial tumor suppressor 1
    transcription factor MTSG1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395000.1 → NP_001381929.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      B1A2U8
      Related
      ENSRNOP00000069962.1, ENSRNOT00000079006.2
      Conserved Domains (1) summary
      TIGR02168
      Location:835 → 1154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_178093.2 → NP_835194.2  microtubule-associated tumor suppressor 1 homolog isoform 2

      See identical proteins and their annotated locations for NP_835194.2

      Status: VALIDATED

      Source sequence(s)
      BC072537
      UniProtKB/Swiss-Prot
      Q6IMY1, Q6XUU5, Q80Z99
      UniProtKB/TrEMBL
      A6JPU4, I7GGY1
      Related
      ENSRNOP00000030995.2, ENSRNOT00000037685.6
      Conserved Domains (1) summary
      TIGR02168
      Location:66 → 385
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      57905991..58051466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253181.5 → XP_006253243.1  microtubule-associated tumor suppressor 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006253243.1

      UniProtKB/TrEMBL
      B1A2U8
      Conserved Domains (1) summary
      TIGR02168
      Location:835 → 1154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_063275428.1 → XP_063131498.1  microtubule-associated tumor suppressor 1 homolog isoform X1

    3. XM_017600120.3 → XP_017455609.1  microtubule-associated tumor suppressor 1 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZY91, I7GGY1
      Related
      ENSRNOP00000084500.1

    4. XM_006253182.5 → XP_006253244.1  microtubule-associated tumor suppressor 1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006253244.1

      UniProtKB/TrEMBL
      D2XRB8
      Related
      ENSRNOP00000070944.1
      Conserved Domains (2) summary
      pfam09755
      Location:193 → 460
      DUF2046; Uncharacterized conserved protein H4 (DUF2046)
      cl19219
      Location:330 → 406
      DUF342; Protein of unknown function (DUF342)

    5. XM_017600121.3 → XP_017455610.1  microtubule-associated tumor suppressor 1 homolog isoform X4

      UniProtKB/TrEMBL
      I7GGY1

    6. XM_017600122.3 → XP_017455611.1  microtubule-associated tumor suppressor 1 homolog isoform X5

      UniProtKB/TrEMBL
      A0A8L2QL23, I7GGY1
      Related
      ENSRNOP00000042990.3

    7. XM_039094527.2 → XP_038950455.1  microtubule-associated tumor suppressor 1 homolog isoform X6

      Conserved Domains (1) summary
      TIGR02168
      Location:14 → 291
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_010058295.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IMY1.1 GenPept UniProtKB/Swiss-Prot:Q6IMY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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