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    Trmt6 tRNA methyltransferase 6 non-catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311441, updated on 2-May-2024

    Summary

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    Official Symbol
    Trmt6provided by RGD
    Official Full Name
    tRNA methyltransferase 6 non-catalytic subunitprovided by RGD
    Primary source
    RGD:1308877
    See related
    Ensembl:ENSRNOG00000021270 AllianceGenome:RGD:1308877
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308877
    Summary
    Predicted to be involved in mRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 105.5), Spleen (RPKM 100.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trmt6 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140527785..140539520, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (120074899..120086639, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125458692..125470413, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene shieldin complex subunit 1 Neighboring gene U6 spliceosomal RNA Neighboring gene chromogranin B Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene cardiolipin synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Li X, et al. Mol Cell, 2017 Dec 7. PMID 29107537, Free PMC Article
    2. The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Safra M, et al. Nature, 2017 Nov 9. PMID 29072297
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
    Names
    tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6
    tRNA methyltransferase 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107779.1 → NP_001101249.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

      See identical proteins and their annotated locations for NP_001101249.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HQH3, D3ZVK3
      Conserved Domains (1) summary
      pfam04189
      Location:21 → 261
      Gcd10p; Gcd10p family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      140527785..140539520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105013.2 → XP_038960941.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X1

      UniProtKB/TrEMBL
      A6HQH3, D3ZVK3
      Related
      ENSRNOP00000028893.5
      Conserved Domains (1) summary
      pfam04189
      Location:21 → 261
      Gcd10p; Gcd10p family

    2. XM_063283784.1 → XP_063139854.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X2

    RNA

    1. XR_005501885.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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