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    Marchf5 membrane associated ring-CH-type finger 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294079, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Marchf5provided by RGD
    Official Full Name
    membrane associated ring-CH-type finger 5provided by RGD
    Primary source
    RGD:1305617
    See related
    Ensembl:ENSRNOG00000017396 AllianceGenome:RGD:1305617
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    March5; Rnf153
    Summary
    Predicted to enable GTPase binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of cell aging; positive regulation of mitochondrial fission; and protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane and mitochondrial outer membrane. Orthologous to human MARCHF5 (membrane associated ring-CH-type finger 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 326.9), Muscle (RPKM 279.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Marchf5 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (244343674..244365160)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234931137..234953849)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (255842642..255864131)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27a, pseudogene 28 Neighboring gene B-TFIID TATA-box binding protein associated factor 1 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102549247

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia. Matsuno K, et al. J Biochem, 2020 Sep 1. PMID 32302394
    2. The mitochondrial ubiquitin ligase plays an anti-apoptotic role in cardiomyocytes by regulating mitochondrial fission. Wang J, et al. J Cell Mol Med, 2016 Dec. PMID 27444773, Free PMC Article
    3. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. Karbowski M, et al. J Cell Biol, 2007 Jul 2. PMID 17606867, Free PMC Article
    4. Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. Park YY, et al. J Cell Sci, 2010 Feb 15. PMID 20103533, Free PMC Article
    5. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. Yonashiro R, et al. EMBO J, 2006 Aug 9. PMID 16874301, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia.
      Title: MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia.
    2. These findings suggest that MITOL plays a protective role against apoptosis in cardiomyocytes.
      Title: The mitochondrial ubiquitin ligase plays an anti-apoptotic role in cardiomyocytes by regulating mitochondrial fission.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF5
    Names
    E3 ubiquitin-protein ligase MARCH5
    membrane-associated ring finger (C3HC4) 5
    ring finger protein 153
    NP_001099842.1
    XP_008758589.1
    XP_038965166.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106372.2 → NP_001099842.1  E3 ubiquitin-protein ligase MARCHF5

      See identical proteins and their annotated locations for NP_001099842.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158801
      UniProtKB/TrEMBL
      A0A8I5YBR0, B0BNF6
      Related
      ENSRNOP00000077306.1, ENSRNOT00000101763.1
      Conserved Domains (1) summary
      cd16701
      Location:12 → 72
      RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      244343674..244365160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760367.3 → XP_008758589.1  E3 ubiquitin-protein ligase MARCHF5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBR0, F7FGS9
      Related
      ENSRNOP00000023562.6, ENSRNOT00000023562.7
      Conserved Domains (1) summary
      cd16701
      Location:12 → 72
      RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)

    2. XM_039109238.2 → XP_038965166.1  E3 ubiquitin-protein ligase MARCHF5 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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