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    ZNF853 zinc finger protein 853 [ Homo sapiens (human) ]

    Gene ID: 54753, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF853provided by HGNC
    Official Full Name
    zinc finger protein 853provided by HGNC
    Primary source
    HGNC:HGNC:21767
    See related
    Ensembl:ENSG00000236609 AllianceGenome:HGNC:21767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 5.7), brain (RPKM 5.5) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF853 in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6615610..6624290)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6734792..6743476)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6655241..6663921)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 4 Neighboring gene uncharacterized LOC124901582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6628794-6629632 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:6637314-6637506 Neighboring gene integrator complex subunit 15 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6653371-6654124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6654125-6654878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6663565-6664065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25632 Neighboring gene Sharpr-MPRA regulatory region 15225 Neighboring gene zinc finger protein 316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6698799-6699300 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:6703791-6704291 Neighboring gene uncharacterized LOC124901583

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Imbeault M, et al. Nature, 2017 Mar 23. PMID 28273063
    2. Cys2His2 zinc finger protein family: classification, functions, and major members. Razin SV, et al. Biochemistry (Mosc), 2012 Mar. PMID 22803940
    3. A quantitative atlas of mitotic phosphorylation. Dephoure N, et al. Proc Natl Acad Sci U S A, 2008 Aug 5. PMID 18669648, Free PMC Article
    4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp547K054, DKFZp434J1015

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 853

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353546.2 → NP_001340475.1  zinc finger protein 853 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073343, BG056932
      Conserved Domains (2) summary
      COG5048
      Location:469 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_017560.3 → NP_060030.1  zinc finger protein 853 isoform 1

      See identical proteins and their annotated locations for NP_060030.1

      Status: VALIDATED

      Source sequence(s)
      AC073343, BG056932
      Consensus CDS
      CCDS59048.1
      UniProtKB/Swiss-Prot
      P0CG23
      Related
      ENSP00000455585.1, ENST00000457543.4
      Conserved Domains (3) summary
      COG5048
      Location:484 → 615
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:515 → 535
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:583 → 608
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      6615610..6624290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515439.4 → XP_011513741.1  zinc finger protein 853 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:522 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:526 → 546
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:594 → 619
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011515438.4 → XP_011513740.1  zinc finger protein 853 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:537 → 590
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:541 → 561
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:609 → 634
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      6734792..6743476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358515.1 → XP_054214490.1  zinc finger protein 853 isoform X2

    2. XM_054358514.1 → XP_054214489.1  zinc finger protein 853 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CG23.1 GenPept UniProtKB/Swiss-Prot:P0CG23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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