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    XPO7 exportin 7 [ Homo sapiens (human) ]

    Gene ID: 23039, updated on 5-Mar-2024

    Summary

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    Official Symbol
    XPO7provided by HGNC
    Official Full Name
    exportin 7provided by HGNC
    Primary source
    HGNC:HGNC:14108
    See related
    Ensembl:ENSG00000130227 MIM:606140; AllianceGenome:HGNC:14108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EXP7; RANBP16
    Summary
    The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
    Expression
    Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 15.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See XPO7 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (21919662..22006585)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22193645..22280568)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21777173..21864096)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene GDNF family receptor alpha 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21683000-21683544 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21683545-21684088 Neighboring gene olfactory receptor family 6 subfamily R member 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21761370-21762198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18974 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21802075-21802708 Neighboring gene uncharacterized LOC124901903 Neighboring gene docking protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21806752-21807252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27071 Neighboring gene VISTA enhancer hs783 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21867514-21868173 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21868174-21868832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21880733-21881446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21881447-21882159 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21893938-21894622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21894623-21895307 Neighboring gene VISTA enhancer hs782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903342-21903848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903849-21904354 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene fibroblast growth factor 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence. Innes AJ, et al. Genes Dev, 2021 Mar 1. PMID 33602872, Free PMC Article
    2. Xpo7 is a broad-spectrum exportin and a nuclear import receptor. Aksu M, et al. J Cell Biol, 2018 Jul 2. PMID 29748336, Free PMC Article
    3. Tumor-specific mutations in low-frequency genes affect their functional properties. Erdem-Eraslan L, et al. J Neurooncol, 2015 May. PMID 25694352, Free PMC Article
    4. Multiple exportins influence thyroid hormone receptor localization. Subramanian KS, et al. Mol Cell Endocrinol, 2015 Aug 15. PMID 25911113, Free PMC Article
    5. RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer. Cáceres-Gorriti KY, et al. PLoS One, 2014. PMID 24625450, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRISPR-based screening identifies XPO7 as a positive regulator of senescence.
      Title: CRISPR-based screening identifies XPO7 as a positive regulator of senescence.
    2. Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
      Title: Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
    3. XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence.
      Title: XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence.
    4. This establishes Xpo7 as a broad-spectrum bidirectional transporter and paves the way for a much deeper analysis of exportin and importin function in the future.
      Title: Xpo7 is a broad-spectrum exportin and a nuclear import receptor.
    5. Knockdown of exportins 4, 5, and 7 altered thyroid hormone receptor shuttling dynamics, and when exportins 5 and 7 were overexpressed, TR distribution shifted toward the cytosol.
      Title: Multiple exportins influence thyroid hormone receptor localization.
    6. Human oligodendrogliomas cells stably expressing mutant XPO7 showed altered cell proliferation.
      Title: Tumor-specific mutations in low-frequency genes affect their functional properties.
    7. RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 have roles in serous epithelial ovarian cancer
      Title: RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer.
    8. Knockdown of XPO7 reduced the amount of nuclear p65 following TNF stimulation. XPO7 binding to p65 is NLS independent
      Title: KPNB1, XPO7 and IPO8 mediate the translocation ofNF-κB/p65 into the nucleus.
    9. These biochemical and functional data reveal RANBP16 and RANBP17 as novel regulators of E2A protein action, and demonstrate specific interaction of E12 with RANBP17.
      Title: Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.
    10. STRADalpha facilitates nuclear export of LKB1 by serving as an adaptor between LKB1 and exportins CRM1 and exportin7.
      Title: STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0745

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear export signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exportin-7
    Names
    RAN binding protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100161.2 → NP_001093631.1  exportin-7 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC087363, AF064729, BC014219, CN479571, DB460798, DC332379
      UniProtKB/TrEMBL
      A8K607
      Conserved Domains (2) summary
      smart00913
      Location:30 → 96
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:29 → 314
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    2. NM_001362802.2 → NP_001349731.1  exportin-7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC087363, AF064729, BC014219, CN479571, DB460798
      UniProtKB/TrEMBL
      A8K607
      Conserved Domains (2) summary
      smart00913
      Location:30 → 96
      IBN_N; Importin-beta N-terminal domain
      cl26694
      Location:29 → 283
      Xpo1; Exportin 1-like protein

    3. NM_015024.5 → NP_055839.3  exportin-7 isoform b

      See identical proteins and their annotated locations for NP_055839.3

      Status: VALIDATED

      Source sequence(s)
      AC087363, AF064729, BC014219, CN479571, DB460798
      Consensus CDS
      CCDS47818.1
      UniProtKB/Swiss-Prot
      O94846, Q6PJK9, Q8NEK7, Q9UIA9
      UniProtKB/TrEMBL
      A8K607
      Related
      ENSP00000252512.9, ENST00000252512.14
      Conserved Domains (2) summary
      smart00913
      Location:30 → 96
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:29 → 305
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    RNA

    1. NR_156173.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087363, AC091171, AF064729, BC014219, CN479571, DB460798

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      21919662..22006585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      22193645..22280568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001100162.1: Suppressed sequence

      Description
      NM_001100162.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UIA9.3 GenPept UniProtKB/Swiss-Prot:Q9UIA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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