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    HOTTIP HOXA distal transcript antisense RNA [ Homo sapiens (human) ]

    Gene ID: 100316868, updated on 8-Mar-2024

    Summary

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    Official Symbol
    HOTTIPprovided by HGNC
    Official Full Name
    HOXA distal transcript antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:37461
    See related
    MIM:614060; AllianceGenome:HGNC:37461
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOXA-AS6; HOXA13-AS1; NCRNA00213
    Summary
    This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in colon (RPKM 4.0), prostate (RPKM 3.7) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HOTTIP in Genome Data Viewer
    Location:
    7p15.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (27200421..27207259)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (27336410..27343254)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27240040..27246878)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27225097-27225978 Neighboring gene HOXA11 antisense RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27231749-27232306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27232307-27232864 Neighboring gene NUP98-HOXA13 recombination region Neighboring gene homeobox A13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27242057-27242581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27244076-27244800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27244801-27245523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27249966-27250466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27250467-27250967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27252523-27253272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27253273-27254021 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27259729-27260290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27264497-27265180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27282039-27282916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27284838-27285446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27285447-27286056 Neighboring gene EVX1 antisense RNA Neighboring gene VISTA enhancer hs629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27290949-27291652 Neighboring gene even-skipped homeobox 1 Neighboring gene ribosomal protein L35 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Computationally Constructed lncRNA-Associated Competing Triplet Network in Clear Cell Renal Cell Carcinoma. Zhang H, et al. Dis Markers, 2022. PMID 36438902, Free PMC Article
    2. Long Non-Coding RNA HOTTIP is Elevated in Patients with Sepsis and Promotes Cardiac Dysfunction. Fan H, et al. Immunol Invest, 2022 Oct. PMID 35921152
    3. LncRNA HOTTIP facilitates osteogenic differentiation in bone marrow mesenchymal stem cells and induces angiogenesis via interacting with TAF15 to stabilize DLX2. Zeng X, et al. Exp Cell Res, 2022 Aug 15. PMID 35644412
    4. M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway. Jiang H, et al. Cell Death Dis, 2022 Feb 24. PMID 35210436, Free PMC Article
    5. HOTTIP is upregulated in esophageal cancer and triggers the drug resistance. Li Y, et al. J BUON, 2021 May-Jun. PMID 34268972

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA HOTTIP exerts an oncogenic function by regulating HOXA13 in nasopharyngeal carcinoma.
      Title: Long non-coding RNA HOTTIP exerts an oncogenic function by regulating HOXA13 in nasopharyngeal carcinoma.
    2. LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
      Title: LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
    3. A Computationally Constructed lncRNA-Associated Competing Triplet Network in Clear Cell Renal Cell Carcinoma.
      Title: A Computationally Constructed lncRNA-Associated Competing Triplet Network in Clear Cell Renal Cell Carcinoma.
    4. Long Non-Coding RNA HOTTIP is Elevated in Patients with Sepsis and Promotes Cardiac Dysfunction.
      Title: Long Non-Coding RNA HOTTIP is Elevated in Patients with Sepsis and Promotes Cardiac Dysfunction.
    5. LncRNA HOTTIP facilitates osteogenic differentiation in bone marrow mesenchymal stem cells and induces angiogenesis via interacting with TAF15 to stabilize DLX2.
      Title: LncRNA HOTTIP facilitates osteogenic differentiation in bone marrow mesenchymal stem cells and induces angiogenesis via interacting with TAF15 to stabilize DLX2.
    6. M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-kappaB pathway.
      Title: M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway.
    7. Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1alpha/VEGF signaling.
      Title: Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling.
    8. HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia.
      Title: HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia.
    9. HOTTIP is upregulated in esophageal cancer and triggers the drug resistance.
      Title: HOTTIP is upregulated in esophageal cancer and triggers the drug resistance.
    10. LncRNA HOTTIP inhibits cell pyroptosis by targeting miR-148a-3p/AKT2 axis in ovarian cancer.
      Title: LncRNA HOTTIP inhibits cell pyroptosis by targeting miR-148a-3p/AKT2 axis in ovarian cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • HOXA cluster antisense RNA 6 (non-protein coding)
    • HOXA distal transcript antisense RNA (non-protein coding)
    • HOXA13 antisense RNA 1 (non-protein coding)
    • HoxA transcript at the distal tip

    Clone Names

    • FLJ36668

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_037843.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004080

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      27200421..27207259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      27336410..27343254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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