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    IGFBP2 insulin like growth factor binding protein 2 [ Gallus gallus (chicken) ]

    Gene ID: 396315, updated on 6-Jun-2024

    Summary

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    Symbol
    IGFBP2provided by CGNC
    Full Name
    insulin like growth factor binding protein 2provided by CGNC
    Primary source
    CGNC:8714
    See related
    Ensembl:ENSGALG00010019282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    IGFBP-2
    Orthologs
    human mouse all
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    Genomic context

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    See IGFBP2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (22879236..22951723, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (22799138..22871611, complement)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101750072 Neighboring gene uncharacterized LOC107053888 Neighboring gene insulin like growth factor binding protein 5 Neighboring gene ribosomal protein L37a Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A polymorphism in the 3'-flanking region of insulin-like growth factor binding protein 2 gene associated with abdominal fat in chickens. Leng L, et al. Poult Sci, 2009 May. PMID 19359680
    2. Identification of a single nucleotide polymorphism of the insulin-like growth factor binding protein 2 gene and its association with growth and body composition traits in the chicken. Li ZH, et al. J Anim Sci, 2006 Nov. PMID 17032782
    3. Cloning and characterization of a chick embryo cDNA and gene for IGF-binding protein-2. Schoen TJ, et al. J Mol Endocrinol, 1995 Aug. PMID 8546813
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The research suggests that the IGFBP2 gene could be a candidate locus or linked to a major gene that affects fatness traits in chickens.
      Title: A polymorphism in the 3'-flanking region of insulin-like growth factor binding protein 2 gene associated with abdominal fat in chickens.
    2. The effect of single nucleotide polymorphisms on body composition, body weight, and other traits in chickens are reported.
      Title: Identification of a single nucleotide polymorphism of the insulin-like growth factor binding protein 2 gene and its association with growth and body composition traits in the chicken.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables insulin-like growth factor I binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin-like growth factor II binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 2
    Names
    IBP-2
    IGF binding protein 2
    insulin-like growth factor binding protein 2, 36kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205359.2 → NP_990690.2  insulin-like growth factor-binding protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/Swiss-Prot
      P49705
      UniProtKB/TrEMBL
      F1P1I0
      Related
      ENSGALP00010027764.1, ENSGALT00010046621.1
      Conserved Domains (2) summary
      smart00121
      Location:40 → 118
      IB; Insulin growth factor-binding protein homologues
      cd00191
      Location:211 → 291
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      22879236..22951723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025152152.2 → XP_025007920.2  insulin-like growth factor-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      Q802T1
      Conserved Domains (1) summary
      cd00191
      Location:114 → 194
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    2. XM_025152153.2 → XP_025007921.1  insulin-like growth factor-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      Q802T1
      Conserved Domains (1) summary
      cd00191
      Location:89 → 169
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    3. XM_025152151.2 → XP_025007919.1  insulin-like growth factor-binding protein 2 isoform X2

      Conserved Domains (1) summary
      cd00191
      Location:123 → 203
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    4. XM_046943498.1 → XP_046799454.1  insulin-like growth factor-binding protein 2 isoform X7

    5. XM_046943497.1 → XP_046799453.1  insulin-like growth factor-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      Q802T1

    6. XM_015289789.3 → XP_015145275.1  insulin-like growth factor-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q802T1
      Conserved Domains (1) summary
      pfam00086
      Location:112 → 191
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    7. XM_046943496.1 → XP_046799452.1  insulin-like growth factor-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      Q802T1

    8. XM_046943499.1 → XP_046799455.1  insulin-like growth factor-binding protein 2 isoform X7

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      22799138..22871611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921150.1 → XP_046777106.1  insulin-like growth factor-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      Q802T1

    2. XM_046921153.1 → XP_046777109.1  insulin-like growth factor-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      Q802T1

    3. XM_046921155.1 → XP_046777111.1  insulin-like growth factor-binding protein 2 isoform X7

    4. XM_046921154.1 → XP_046777110.1  insulin-like growth factor-binding protein 2 isoform X7

    5. XM_046921151.1 → XP_046777107.1  insulin-like growth factor-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q802T1

    6. XM_046921152.1 → XP_046777108.1  insulin-like growth factor-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      Q802T1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49705.1 GenPept UniProtKB/Swiss-Prot:P49705

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    Research Materials