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    ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 491368, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ITIH3provided by VGNC
    Official Full Name
    inter-alpha-trypsin inhibitor heavy chain 3provided by VGNC
    Primary source
    VGNC:VGNC:103686
    See related
    Ensembl:ENSCAFG00845029600
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See ITIH3 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (37372140..37386102, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (37003374..37017395, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (37421715..37435675, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (37144184..37158164, complement)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain H1-like Neighboring gene uncharacterized LOC119864681 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene uncharacterized LOC119864680 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 1 Neighboring gene NIMA related kinase 4 Neighboring gene ATP synthase subunit g, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H3
    Names
    inter-alpha (globulin) inhibitor H3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      37372140..37386102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038427518.1 → XP_038283446.1  inter-alpha-trypsin inhibitor heavy chain H3

      UniProtKB/TrEMBL
      A0A8C0M8V3, A0A8I3QUR2, A0A8P0SJ97
      Related
      ENSCAFP00845041141.1, ENSCAFT00845052439.1
      Conserved Domains (3) summary
      smart00609
      Location:30 → 158
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:281 → 462
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      pfam06668
      Location:684 → 872
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      37144184..37158164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038630343.1 → XP_038486271.1  inter-alpha-trypsin inhibitor heavy chain H3

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      37421715..37435675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038566177.1 → XP_038422105.1  inter-alpha-trypsin inhibitor heavy chain H3

      UniProtKB/TrEMBL
      A0A8C0M8V3

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      37003374..37017395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038455172.1 → XP_038311100.1  inter-alpha-trypsin inhibitor heavy chain H3

      UniProtKB/TrEMBL
      A0A8C0M8V3, A0A8I3QUR2, A0A8P0SJ97
      Conserved Domains (3) summary
      smart00609
      Location:30 → 158
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:281 → 462
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      pfam06668
      Location:684 → 872
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    Nucleotide Protein
    Heading Accession and Version

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