Pex5l peroxisomal biogenesis factor 5-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pex5lprovided by MGI
Official Full Name: peroxisomal biogenesis factor 5-likeprovided by MGI
Primary source: MGI:MGI:1916672
See related: Ensembl:ENSMUSG00000027674 AllianceGenome:MGI:1916672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PXR2; Pex2; TRIP8b; pex5Rp; 1700016J08Rik
Summary: Predicted to enable intracellular cyclic nucleotide activated cation channel activity; peroxisome matrix targeting signal-1 binding activity; and small GTPase binding activity. Acts upstream of or within maintenance of protein location and regulation of membrane potential. Located in cytoplasm and dendrite. Is expressed in brain and retina outer nuclear layer. Orthologous to human PEX5L (peroxisomal biogenesis factor 5 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 17.5), cerebellum adult (RPKM 16.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 15.94 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (33002075..33197470, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (32947926..33143302, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice.
Title: Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice.
loss of TRIP8b phosphorylation may affect HCN channel properties during epileptogenesis.
Title: Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function.
This study found that global loss of TRIP8b, a necessary subunit for proper HCN channel localization in pyramidal cells, led to active coping behavior in numerous assays specific to coping style.
Title: HCN channels in the hippocampus regulate active coping behavior.
This study demonstrated that Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) in regulation of hyperpolarization-activated inward current, I h, in the thalamocortical system and its functional relevance
Title: Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels.
Study characterized the effects of deletion of the HCN channel auxiliary subunit TRIP8b in the mouse thalamus and cortex, focusing on electrophysiological changes and their role in promoting absence epilepsy
Title: Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.
We conclude that TRIP8b in the retina is needed to achieve maximal expression of HCN1.
Title: TRIP8b is required for maximal expression of HCN1 in the mouse retina.
TRIP8b deletion is not restricted to the integrative properties of neurons but also includes both synaptic and intrinsic plasticity
Title: Short- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b.
TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons.
Title: Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.
Study links elevated MMP-2/PEX2 to ischemia and poor wound healing.
Title: Elevation of hemopexin-like fragment of matrix metalloproteinase-2 tissue levels inhibits ischemic wound healing and angiogenesis.
increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively.
Title: Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Mit181 (e-PCR), detects polymorphism
- UniSTS:129601

D3Mit181.2 (e-PCR), detects polymorphism
- UniSTS:129602

D3Mit272 (e-PCR), detects polymorphism
- UniSTS:129700

D3Mit273 (e-PCR), detects polymorphism
- UniSTS:129701

D9S1872 (e-PCR)
- UniSTS:61945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables peroxisome matrix targeting signal-1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome matrix targeting signal-1 binding	ISO Inferred from Sequence Orthology more info
enables peroxisome targeting sequence binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within maintenance of protein location	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell tip	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of intracellular cyclic nucleotide activated cation channel complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: PEX5-related protein

Names: PEX2-related protein; PEX5-like protein; peroxin 2; peroxin-5-related protein; peroxisomal targeting signal 1 receptor-like; tetratricopeptide repeat-containing Rab8b-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163516.3 → NP_001156988.1 PEX5-related protein isoform 2

See identical proteins and their annotated locations for NP_001156988.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and lacks a portion of the 5' coding region compared to variant 5. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 5.

Source sequence(s)

AC119877, AK083141, CB519585, CX236501, HQ646192

Consensus CDS

CCDS50889.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLP9

Related

ENSMUSP00000103861.2, ENSMUST00000108226.8

Conserved Domains (3) summary

sd00006
Location:415 → 443

TPR; TPR repeat [structural motif]

pfam00515
Location:452 → 482

TPR_1; Tetratricopeptide repeat

pfam13414
Location:414 → 480

TPR_11; TPR repeat
NM_001163517.3 → NP_001156989.1 PEX5-related protein isoform 3

See identical proteins and their annotated locations for NP_001156989.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an in-frame downstream start codon compared to variant 5. The encoded isoform (3) has a shorter N-terminus than isoform 5.

Source sequence(s)

AC119877, AK006035, AK083141, CB519585, HQ646192

Consensus CDS

CCDS50888.1

UniProtKB/TrEMBL

F8SLQ6

Related

ENSMUSP00000103856.2, ENSMUST00000108221.2

Conserved Domains (2) summary

TIGR02917
Location:55 → 292

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:192 → 220

TPR; TPR repeat [structural motif]
NM_001289505.2 → NP_001276434.1 PEX5-related protein isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences compared to variant 5. The encoded isoform (4) is shorter than isoform 5.

Source sequence(s)

AC116723, AC119877, AK039764, CB519585, HQ646192

Consensus CDS

CCDS79893.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

D3YYH0

Related

ENSMUSP00000103859.2, ENSMUST00000108224.8

Conserved Domains (3) summary

sd00006
Location:439 → 467

TPR; TPR repeat [structural motif]

pfam00515
Location:476 → 506

TPR_1; Tetratricopeptide repeat

pfam13414
Location:438 → 504

TPR_11; TPR repeat
NM_001310460.1 → NP_001297389.1 PEX5-related protein isoform 5

See identical proteins and their annotated locations for NP_001297389.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).

Source sequence(s)

AC119877, CB519585, HQ646192

Consensus CDS

CCDS79894.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLQ1

Related

ENSMUSP00000141454.2, ENSMUST00000193681.6

Conserved Domains (2) summary

TIGR02917
Location:361 → 598

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:498 → 526

TPR; TPR repeat [structural motif]
NM_021483.5 → NP_067458.2 PEX5-related protein isoform 1

See identical proteins and their annotated locations for NP_067458.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region compared to variant 5. The encoded isoform (1) is shorter than isoform 5.

Source sequence(s)

AC116723, AC119877, AK039764, CB519585, HQ646192

Consensus CDS

CCDS17302.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLQ3

Related

ENSMUSP00000141387.2, ENSMUST00000192093.6

Conserved Domains (2) summary

TIGR02917
Location:326 → 563

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:463 → 491

TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

33002075..33197470 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535506.5 → XP_006535569.1 PEX5-related protein isoform X14

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:314 → 551

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:451 → 479

TPR; TPR repeat [structural motif]
XM_006535507.3 → XP_006535570.1 PEX5-related protein isoform X15

See identical proteins and their annotated locations for XP_006535570.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLP8

Conserved Domains (2) summary

TIGR02917
Location:313 → 550

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:450 → 478

TPR; TPR repeat [structural motif]
XM_011249701.2 → XP_011248003.1 PEX5-related protein isoform X17

See identical proteins and their annotated locations for XP_011248003.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLP7

Conserved Domains (2) summary

TIGR02917
Location:302 → 539

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:439 → 467

TPR; TPR repeat [structural motif]
XM_011249697.4 → XP_011247999.1 PEX5-related protein isoform X9

See identical proteins and their annotated locations for XP_011247999.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLP6

Conserved Domains (2) summary

TIGR02917
Location:337 → 574

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:474 → 502

TPR; TPR repeat [structural motif]
XM_011249696.4 → XP_011247998.1 PEX5-related protein isoform X8

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:338 → 575

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:475 → 503

TPR; TPR repeat [structural motif]
XM_011249694.4 → XP_011247996.1 PEX5-related protein isoform X6

See identical proteins and their annotated locations for XP_011247996.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLP5

Conserved Domains (2) summary

TIGR02917
Location:359 → 596

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:496 → 524

TPR; TPR repeat [structural motif]
XM_011249693.3 → XP_011247995.1 PEX5-related protein isoform X5

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:360 → 597

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:497 → 525

TPR; TPR repeat [structural motif]
XM_006535508.3 → XP_006535571.1 PEX5-related protein isoform X21

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:279 → 516

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:416 → 444

TPR; TPR repeat [structural motif]
XM_036163200.1 → XP_036019093.1 PEX5-related protein isoform X16

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:303 → 540

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:440 → 468

TPR; TPR repeat [structural motif]
XM_036163203.1 → XP_036019096.1 PEX5-related protein isoform X22

Conserved Domains (2) summary

TIGR02917
Location:145 → 382

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:282 → 310

TPR; TPR repeat [structural motif]
XM_036163202.1 → XP_036019095.1 PEX5-related protein isoform X20

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:294 → 531

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:431 → 459

TPR; TPR repeat [structural motif]
XM_011249703.3 → XP_011248005.1 PEX5-related protein isoform X19

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:295 → 532

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:432 → 460

TPR; TPR repeat [structural motif]
XM_011249702.3 → XP_011248004.1 PEX5-related protein isoform X18

See identical proteins and their annotated locations for XP_011248004.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLQ5

Conserved Domains (2) summary

TIGR02917
Location:301 → 538

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:438 → 466

TPR; TPR repeat [structural motif]
XM_011249698.3 → XP_011248000.1 PEX5-related protein isoform X11

See identical proteins and their annotated locations for XP_011248000.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLQ4

Conserved Domains (2) summary

TIGR02917
Location:336 → 573

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:473 → 501

TPR; TPR repeat [structural motif]
XM_030252740.1 → XP_030108600.1 PEX5-related protein isoform X10

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:337 → 574

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:474 → 502

TPR; TPR repeat [structural motif]
XM_011249695.3 → XP_011247997.1 PEX5-related protein isoform X7

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:359 → 596

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:496 → 524

TPR; TPR repeat [structural motif]
XM_011249692.3 → XP_011247994.1 PEX5-related protein isoform X4

See identical proteins and their annotated locations for XP_011247994.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLQ1

Related

ENSMUSP00000142008.2, ENSMUST00000193289.6

Conserved Domains (2) summary

TIGR02917
Location:361 → 598

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:498 → 526

TPR; TPR repeat [structural motif]
XM_011249689.3 → XP_011247991.1 PEX5-related protein isoform X1

See identical proteins and their annotated locations for XP_011247991.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:384 → 621

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:521 → 549

TPR; TPR repeat [structural motif]
XM_011249700.3 → XP_011248002.1 PEX5-related protein isoform X13

See identical proteins and their annotated locations for XP_011248002.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

UniProtKB/TrEMBL

F8SLQ3

Conserved Domains (2) summary

TIGR02917
Location:326 → 563

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:463 → 491

TPR; TPR repeat [structural motif]
XM_011249699.3 → XP_011248001.1 PEX5-related protein isoform X12

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:327 → 564

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:464 → 492

TPR; TPR repeat [structural motif]
XM_011249691.3 → XP_011247993.1 PEX5-related protein isoform X3

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:362 → 599

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:499 → 527

TPR; TPR repeat [structural motif]
XM_011249690.3 → XP_011247992.1 PEX5-related protein isoform X2

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:383 → 620

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:520 → 548

TPR; TPR repeat [structural motif]
XM_011249688.3 → XP_011247990.1 PEX5-related protein isoform X1

See identical proteins and their annotated locations for XP_011247990.1

UniProtKB/Swiss-Prot

Q8C437, Q8CA31, Q9DAA1, Q9JMB9

Conserved Domains (2) summary

TIGR02917
Location:384 → 621

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:521 → 549

TPR; TPR repeat [structural motif]