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    ADGRF2 adhesion G protein-coupled receptor F2 [ Homo sapiens (human) ]

    Gene ID: 222611, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ADGRF2provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor F2provided by HGNC
    Primary source
    HGNC:HGNC:18991
    See related
    AllianceGenome:HGNC:18991
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR20; GPR111; hGPCR35
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in skin (RPKM 1.2), esophagus (RPKM 0.3) and 1 other tissue See more
    Orthologs
    all
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    Genomic context

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    See ADGRF2 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (47656472..47697794)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (47498118..47539580)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (47624208..47665530)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CD2 associated protein Neighboring gene ribosomal protein S12 pseudogene 14 Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:47589053-47590252 Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene RN7SK pseudogene 116 Neighboring gene ribosomal protein L27a pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Fredriksson R, et al. Biochem Biophys Res Commun, 2003 Feb 14. PMID 12565841
    2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. Fredriksson R, et al. FEBS Lett, 2002 Nov 20. PMID 12435584
    3. Identification of G protein-coupled receptor genes from the human genome sequence. Takeda S, et al. FEBS Lett, 2002 Jun 5. PMID 12044878
    4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ADGRF4

    Homology

    Other Names

    • G protein-coupled receptor 111
    • probable G-protein coupled receptor 111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_184444.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356421

    2. NR_184445.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356421

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      47656472..47697794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      47498118..47539580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001368115.2: Suppressed sequence

      Description
      NM_001368115.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    2. NM_001394650.1: Suppressed sequence

      Description
      NM_001394650.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    3. NM_153839.7: Suppressed sequence

      Description
      NM_153839.7: This RefSeq was removed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZF7.1 GenPept UniProtKB/Swiss-Prot:Q8IZF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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