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    Kank4 KN motif and ankyrin repeat domains 4 [ Mus musculus (house mouse) ]

    Gene ID: 242553, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kank4provided by MGI
    Official Full Name
    KN motif and ankyrin repeat domains 4provided by MGI
    Primary source
    MGI:MGI:3043381
    See related
    Ensembl:ENSMUSG00000035407 AllianceGenome:MGI:3043381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ankrd38; C130031J23
    Summary
    Predicted to be involved in negative regulation of actin filament polymerization. Predicted to act upstream of or within negative regulation of stress fiber assembly. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in extrinsic ocular muscle; lung; metanephros; and ureteric tip. Orthologous to human KANK4 (KN motif and ankyrin repeat domains 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 4.5), limb E14.5 (RPKM 4.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kank4 in Genome Data Viewer
    Location:
    4 C6; 4 45.6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (98643129..98706295, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (98754892..98818058, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene PATJ, crumbs cell polarity complex component Neighboring gene STARR-seq mESC enhancer starr_10851 Neighboring gene predicted gene, 35073 Neighboring gene LINE-1 type transposase domain containing 1 Neighboring gene RIKEN cDNA I0C0044D17 gene Neighboring gene KN motif and ankyrin repeat domains 4, opposite strand Neighboring gene STARR-seq mESC enhancer starr_10858 Neighboring gene STARR-seq mESC enhancer starr_10859 Neighboring gene predicted gene 12851

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner. Zhang C, et al. Arterioscler Thromb Vasc Biol, 2022 Jun. PMID 35477278
    2. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. Zhu Y, et al. Biochim Biophys Acta, 2008 Feb. PMID 17996375
    3. Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins. Guo SS, et al. Exp Cell Res, 2021 Jan 1. PMID 33253712
    4. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
    5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner.
      Title: KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner.
    2. Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
      Title: Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 4
    Names
    ankyrin repeat domain 38
    ankyrin repeat domain-containing protein 38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172872.3 → NP_766460.2  KN motif and ankyrin repeat domain-containing protein 4

      See identical proteins and their annotated locations for NP_766460.2

      Status: VALIDATED

      Source sequence(s)
      AL670941
      Consensus CDS
      CCDS18379.1
      UniProtKB/Swiss-Prot
      Q6P9J5, Q8BV03
      Related
      ENSMUSP00000099851.4, ENSMUST00000102790.4
      Conserved Domains (6) summary
      cd00204
      Location:833 → 964
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:24 → 62
      KN_motif; KN motif
      pfam12796
      Location:843 → 941
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:808 → 859
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:930 → 985
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:838 → 870
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      98643129..98706295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240522.3 → XP_011238824.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011238824.1

      Conserved Domains (5) summary
      sd00045
      Location:838 → 877
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:24 → 62
      KN_motif; KN motif
      pfam12796
      Location:922 → 1008
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:808 → 859
      Ank_4; Ankyrin repeats (many copies)
      pfam18595
      Location:328 → 408
      DHR10; Designed helical repeat protein 10 domain

    2. XM_011240523.4 → XP_011238825.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011238825.1

      Conserved Domains (5) summary
      sd00045
      Location:838 → 877
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:24 → 62
      KN_motif; KN motif
      pfam12796
      Location:922 → 1008
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:808 → 859
      Ank_4; Ankyrin repeats (many copies)
      pfam18595
      Location:328 → 408
      DHR10; Designed helical repeat protein 10 domain

    RNA

    1. XR_867859.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9J5.1 GenPept UniProtKB/Swiss-Prot:Q6P9J5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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