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    Fus fused in sarcoma [ Mus musculus (house mouse) ]

    Gene ID: 233908, updated on 12-May-2024

    Summary

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    Official Symbol
    Fusprovided by MGI
    Official Full Name
    fused in sarcomaprovided by MGI
    Primary source
    MGI:MGI:1353633
    See related
    Ensembl:ENSMUSG00000030795 AllianceGenome:MGI:1353633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tls; Fus1; D430004D17Rik; D930039C12Rik
    Summary
    Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study amyotrophic lateral sclerosis type 6. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 160.0), CNS E11.5 (RPKM 159.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fus in Genome Data Viewer
    Location:
    7 F3; 7 69.87 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127565276..127581204)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127966789..127982032)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 8 Neighboring gene serine protease 8 (prostasin) Neighboring gene STARR-positive B cell enhancer ABC_E6608 Neighboring gene serine protease 36 Neighboring gene predicted gene, 53375 Neighboring gene STARR-seq mESC enhancer starr_20197 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif-containing 72

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes. Tzeplaeff L, et al. Prog Neurobiol, 2023 Aug. PMID 37327984
    2. Brain region-specific synaptic function of FUS underlies the FTLD-linked behavioural disinhibition. Wang JY, et al. Brain, 2023 May 2. PMID 36345573
    3. Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation. Sanjuan-Ruiz I, et al. Mol Neurodegener, 2021 Sep 6. PMID 34488813, Free PMC Article
    4. The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation. Reber S, et al. Nucleic Acids Res, 2021 Jul 21. PMID 34233002, Free PMC Article
    5. Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS. Sahadevan S, et al. Nat Commun, 2021 May 21. PMID 34021139, Free PMC Article

    See all (166) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
      Title: FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
    2. Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice.
      Title: Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice.
    3. Aging-disturbed FUS phase transition impairs hematopoietic stem cells by altering chromatin structure.
      Title: Aging-disturbed FUS phase transition impairs hematopoietic stem cells by altering chromatin structure.
    4. CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.
      Title: CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.
    5. Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes.
      Title: Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes.
    6. Brain region-specific synaptic function of FUS underlies the FTLD-linked behavioural disinhibition.
      Title: Brain region-specific synaptic function of FUS underlies the FTLD-linked behavioural disinhibition.
    7. LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS.
      Title: LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS.
    8. Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.
      Title: Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.
    9. circGrm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS.
      Title: circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS.
    10. FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development.
      Title: FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development.
    Submit: New GeneRIF Correction See all GeneRIFs (80)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular non-membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding protein FUS
    Names
    fusion, derived from t(12;16) malignant liposarcoma
    hnRNP P2
    pigpen protein
    protein pigpen
    translocated in liposarcoma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347649.1 → NP_001334578.1  RNA-binding protein FUS isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC124461
      Consensus CDS
      CCDS85425.1
      UniProtKB/TrEMBL
      Q3UK30, Q8CFQ9
      Related
      ENSMUSP00000076801.6, ENSMUST00000077609.12

    2. NM_139149.2 → NP_631888.1  RNA-binding protein FUS isoform 1

      See identical proteins and their annotated locations for NP_631888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK139960, AK145582, BY269119
      Consensus CDS
      CCDS21886.1
      UniProtKB/Swiss-Prot
      P56959
      UniProtKB/TrEMBL
      Q3UK30, Q564D0
      Related
      ENSMUSP00000101858.4, ENSMUST00000106251.10
      Conserved Domains (3) summary
      COG0724
      Location:257 → 367
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:276 → 361
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:415 → 442
      zf-RanBP; Zn-finger in Ran binding protein and others

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127565276..127581204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507760.3 → XP_006507823.1  RNA-binding protein FUS isoform X1

      Conserved Domains (2) summary
      cd12535
      Location:71 → 156
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:211 → 237
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. XM_017322218.3 → XP_017177707.1  RNA-binding protein FUS isoform X1

      Conserved Domains (2) summary
      cd12535
      Location:71 → 156
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:211 → 237
      zf-RanBP; Zn-finger in Ran binding protein and others
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56959.1 GenPept UniProtKB/Swiss-Prot:P56959

    Gene LinkOut

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