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    ZXDA zinc finger X-linked duplicated A [ Homo sapiens (human) ]

    Gene ID: 7789, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZXDAprovided by HGNC
    Official Full Name
    zinc finger X-linked duplicated Aprovided by HGNC
    Primary source
    HGNC:HGNC:13198
    See related
    Ensembl:ENSG00000198205 MIM:300235; AllianceGenome:HGNC:13198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF896
    Summary
    This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009]
    Orthologs
    all
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    Genomic context

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    See ZXDA in Genome Data Viewer
    Location:
    Xp11.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (57905430..57910458, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (57205099..57210129, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57931864..57936892, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MDH1 pseudogene 1 Neighboring gene uncharacterized LOC124905232 Neighboring gene Sharpr-MPRA regulatory region 7453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20873 Neighboring gene MYCL pseudogene 2 Neighboring gene keratin 8 pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. Aleksandrova A, et al. Mol Cell Biochem, 2010 Apr. PMID 19777325, Free PMC Article
    2. Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. Greig GM, et al. Hum Mol Genet, 1993 Oct. PMID 8268913
    3. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. Al-Kandari W, et al. J Mol Biol, 2007 Jun 22. PMID 17493635, Free PMC Article
    4. Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. Jambunathan S, et al. Biol Chem, 2007 Sep. PMID 17696781
    5. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Tarpey PS, et al. Nat Genet, 2009 May. PMID 19377476, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of ZXD proteins in regulating MHC II transcription.
      Title: An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription.
    2. ZXDA and ZXDC form an important regulatory complex for MHC II gene transcription.
      Title: The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger X-linked protein ZXDA
    Names
    zinc finger protein 896

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015974.1 RefSeqGene

      Range
      5176..10204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007156.5 → NP_009087.1  zinc finger X-linked protein ZXDA

      See identical proteins and their annotated locations for NP_009087.1

      Status: REVIEWED

      Source sequence(s)
      AL034396
      Consensus CDS
      CCDS14376.1
      UniProtKB/Swiss-Prot
      P98168, Q9UJP7
      UniProtKB/TrEMBL
      A8K9H1
      Related
      ENSP00000351530.4, ENST00000358697.6
      Conserved Domains (6) summary
      COG5048
      Location:437 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:425 → 444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:512 → 534
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:300 → 324
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:346 → 369
      zf-H2C2_2; Zinc-finger double domain
      pfam17017
      Location:300 → 445
      zf-C2H2_aberr; Aberrant zinc-finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      57905430..57910458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      57205099..57210129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98168.2 GenPept UniProtKB/Swiss-Prot:P98168

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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