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    Nvl nuclear VCP-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289323, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nvlprovided by RGD
    Official Full Name
    nuclear VCP-likeprovided by RGD
    Primary source
    RGD:1311270
    See related
    Ensembl:ENSRNOG00000003629 AllianceGenome:RGD:1311270
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and preribosome binding activity. Predicted to be involved in several processes, including positive regulation of telomerase activity; regulation of protein localization to nucleolus; and ribosome biogenesis. Predicted to be located in nucleoplasm. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleus. Predicted to colocalize with nucleolus. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 74.3), Adrenal (RPKM 65.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nvl in Genome Data Viewer
    Location:
    13q26
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (95385389..95438490, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (92851023..92906749, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (99410026..99468783, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene delta(4)-desaturase, sphingolipid 1 like 1 Neighboring gene ribosomal protein L35, pseudogene 2 Neighboring gene delta(4)-desaturase, sphingolipid 1 like 2 Neighboring gene U6 spliceosomal RNA Neighboring gene cornichon family member 4 Neighboring gene WD repeat domain 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. Her J, et al. Biochem Biophys Res Commun, 2012 Jan 20. PMID 22226966
    2. The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1. Nagahama M, et al. Biochem Biophys Res Commun, 2006 Aug 4. PMID 16782053
    3. NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence. Nagahama M, et al. Mol Biol Cell, 2004 Dec. PMID 15469983, Free PMC Article
    4. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74. Hiraishi N, et al. Biochem Biophys Res Commun, 2015 Nov 20. PMID 26456651
    5. WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2. Hiraishi N, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29107693

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables preribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables preribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of telomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear valosin-containing protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105980.1 → NP_001099450.1  nuclear valosin-containing protein-like

      See identical proteins and their annotated locations for NP_001099450.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A0A0G2JXU1, A6JGJ3, D3ZTY9
      Related
      ENSRNOP00000004927.4, ENSRNOT00000004927.7
      Conserved Domains (2) summary
      TIGR01243
      Location:255 → 855
      CDC48; AAA family ATPase, CDC48 subfamily
      pfam16725
      Location:2 → 71
      Nucleolin_bd; Nucleolin binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      95385389..95438490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250367.5 → XP_006250429.1  nuclear valosin-containing protein-like isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXU1
      Conserved Domains (4) summary
      COG0464
      Location:257 → 816
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:591 → 721
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam16725
      Location:2 → 71
      Nucleolin_bd; Nucleolin binding domain
      cl21455
      Location:571 → 607
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_063272169.1 → XP_063128239.1  nuclear valosin-containing protein-like isoform X2

    3. XM_006250370.4 → XP_006250432.1  nuclear valosin-containing protein-like isoform X3

      UniProtKB/TrEMBL
      A0A0G2JXU1
      Conserved Domains (3) summary
      COG0464
      Location:166 → 725
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:500 → 630
      AAA; ATPase family associated with various cellular activities (AAA)
      cl21455
      Location:480 → 516
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_017598728.3 → XP_017454217.1  nuclear valosin-containing protein-like isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXU1

    5. XM_006250372.5 → XP_006250434.1  nuclear valosin-containing protein-like isoform X4

      UniProtKB/TrEMBL
      A0A0G2JXU1
      Conserved Domains (1) summary
      TIGR01243
      Location:97 → 697
      CDC48; AAA family ATPase, CDC48 subfamily

    6. XM_039090562.2 → XP_038946490.1  nuclear valosin-containing protein-like isoform X4

      UniProtKB/TrEMBL
      A0A0G2JXU1
      Conserved Domains (1) summary
      TIGR01243
      Location:97 → 697
      CDC48; AAA family ATPase, CDC48 subfamily

    7. XM_063272170.1 → XP_063128240.1  nuclear valosin-containing protein-like isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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