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    Rbm12b1 RNA binding motif protein 12 B1 [ Mus musculus (house mouse) ]

    Gene ID: 72397, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rbm12b1provided by MGI
    Official Full Name
    RNA binding motif protein 12 B1provided by MGI
    Primary source
    MGI:MGI:1919647
    See related
    Ensembl:ENSMUSG00000046667 AllianceGenome:MGI:1919647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbm12b; Rbm12ba; 3000004N20Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in central nervous system and olfactory epithelium. Orthologous to human RBM12B (RNA binding motif protein 12B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 5.4), CNS E18 (RPKM 5.1) and 25 other tissues See more
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    Genomic context

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    See Rbm12b1 in Genome Data Viewer
    Location:
    4 A1; 4 5.58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (12138957..12148922)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (12138957..12148922)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene poly A binding protein, cytoplasmic 4 pseudogene Neighboring gene poly A binding protein, cytoplasmic 4 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene CBY1 interacting BAR domain containing 1 Neighboring gene predicted gene, 46845 Neighboring gene predicted gene, 46846

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 12B-A
    Names
    RNA binding motif protein 12B
    RNA-binding motif protein 12B-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028226.2 → NP_082502.2  RNA-binding protein 12B-A

      See identical proteins and their annotated locations for NP_082502.2

      Status: VALIDATED

      Source sequence(s)
      AK013872, AL929413, BC050844, BP767112
      Consensus CDS
      CCDS17976.1
      UniProtKB/Swiss-Prot
      B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
      UniProtKB/TrEMBL
      B2RPV4
      Related
      ENSMUSP00000064195.8, ENSMUST00000069128.8
      Conserved Domains (5) summary
      PTZ00465
      Location:601 → 708
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 559
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      12138957..12148922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538274.2 → XP_006538337.1  RNA-binding protein 12B-A isoform X1

      See identical proteins and their annotated locations for XP_006538337.1

      UniProtKB/Swiss-Prot
      B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:601 → 708
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 559
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_036164456.1 → XP_036020349.1  RNA-binding protein 12B-A isoform X1

      UniProtKB/Swiss-Prot
      B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:601 → 708
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 559
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_006538271.4 → XP_006538334.1  RNA-binding protein 12B-A isoform X1

      See identical proteins and their annotated locations for XP_006538334.1

      UniProtKB/Swiss-Prot
      B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:601 → 708
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 559
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_006538272.4 → XP_006538335.1  RNA-binding protein 12B-A isoform X1

      See identical proteins and their annotated locations for XP_006538335.1

      UniProtKB/Swiss-Prot
      B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
      UniProtKB/TrEMBL
      B2RPV4
      Related
      ENSMUSP00000053555.3, ENSMUST00000050069.9
      Conserved Domains (5) summary
      PTZ00465
      Location:601 → 708
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 559
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_030253810.1 → XP_030109670.1  RNA-binding protein 12B-A isoform X1

      UniProtKB/Swiss-Prot
      B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:601 → 708
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 559
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_006538273.4 → XP_006538336.1  RNA-binding protein 12B-A isoform X1

      See identical proteins and their annotated locations for XP_006538336.1

      UniProtKB/Swiss-Prot
      B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:601 → 708
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 559
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_036164457.1 → XP_036020350.1  RNA-binding protein 12B-A isoform X1

      UniProtKB/Swiss-Prot
      B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:601 → 708
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 559
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YR9.2 GenPept UniProtKB/Swiss-Prot:Q80YR9

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