DND1 DND microRNA-mediated repression inhibitor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DND1provided by HGNC
Official Full Name: DND microRNA-mediated repression inhibitor 1provided by HGNC
Primary source: HGNC:HGNC:23799
See related: Ensembl:ENSG00000256453 MIM:609385; AllianceGenome:HGNC:23799
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RBMS4
Summary: This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]
Expression: Ubiquitous expression in testis (RPKM 7.3), colon (RPKM 6.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (140670794..140673576, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (141196191..141198973, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (140050379..140053161, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1.
Title: Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1.
A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
Title: A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
High DND1 Level Indicates a Poor Prognostic Factor in Prostate Cancer.
Title: High DND1 Level Indicates a Poor Prognostic Factor in Prostate Cancer.
Human DND1-RRM2 forms a non-canonical domain swapped dimer.
Title: Human DND1-RRM2 forms a non-canonical domain swapped dimer.
MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1.
Title: MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1.
Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention.
Title: RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells.
Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR.
Title: RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site.
RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation
Title: The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation.
APOBEC3G inhibits DND1 function to regulate microRNA activity.
Title: APOBEC3 inhibits DEAD-END function to regulate microRNA activity.
The increased sensitivity of transformed keratinocytes to miR-21's effects occurs in part through downregulation of the RNA-binding protein DND1 during the transformation process.
Title: The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-19187 (e-PCR)
- UniSTS:32540

STS-H16567 (e-PCR)
- UniSTS:49615

WI-21153 (e-PCR)
- UniSTS:21715

Hars (e-PCR), detects polymorphism
- UniSTS:143316

RH70258 (e-PCR)
- UniSTS:72933

D5S2775 (e-PCR)
- UniSTS:473843

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of miRNA-mediated gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of miRNA-mediated gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dead end protein homolog 1

Names: RNA-binding motif, single-stranded-interacting protein 4; dead end homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194249.3 → NP_919225.1 dead end protein homolog 1

See identical proteins and their annotated locations for NP_919225.1

Status: REVIEWED

Source sequence(s)

AC116353, BC033496

Consensus CDS

CCDS4236.1

UniProtKB/Swiss-Prot

Q8IYX4

Related

ENSP00000445366.1, ENST00000542735.2

Conserved Domains (2) summary

pfam14709
Location:253 → 333

DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1

cl25617
Location:18 → 219

LSM_int_assoc; LSM-interacting associated unstructured