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    FAM24A family with sequence similarity 24 member A [ Homo sapiens (human) ]

    Gene ID: 118670, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FAM24Aprovided by HGNC
    Official Full Name
    family with sequence similarity 24 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:23470
    See related
    Ensembl:ENSG00000203795 AllianceGenome:HGNC:23470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 5.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See FAM24A in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (122910610..122913111)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (123785583..123788099)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124670126..124672627)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FAM24B-CUZD1 readthrough Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:124605161-124605662 Neighboring gene CUB and zona pellucida like domains 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:124605663-124606162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:124606229-124607110 Neighboring gene Sharpr-MPRA regulatory region 14360 Neighboring gene family with sequence similarity 24 member B Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:124635306-124635826 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:124635827-124636346 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:124644309-124644439 Neighboring gene C10orf88B (pseudogene) Neighboring gene Sharpr-MPRA regulatory region 13232 Neighboring gene chromosome 10 open reading frame 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2894 Neighboring gene uncharacterized LOC124902519

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM24A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029888.3 → NP_001025059.1  protein FAM24A precursor

      See identical proteins and their annotated locations for NP_001025059.1

      Status: VALIDATED

      Source sequence(s)
      AC073585, BX109949
      Consensus CDS
      CCDS31304.1
      UniProtKB/Swiss-Prot
      A6NFZ4
      Related
      ENSP00000357889.1, ENST00000368894.2
      Conserved Domains (1) summary
      pfam15193
      Location:33 → 105
      FAM24; FAM24 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      122910610..122913111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015639.2 → XP_016871128.1  protein FAM24A isoform X1

      UniProtKB/Swiss-Prot
      A6NFZ4
      Conserved Domains (1) summary
      pfam15193
      Location:33 → 105
      FAM24; FAM24 family

    2. XM_017015638.2 → XP_016871127.1  protein FAM24A isoform X1

      UniProtKB/Swiss-Prot
      A6NFZ4
      Conserved Domains (1) summary
      pfam15193
      Location:33 → 105
      FAM24; FAM24 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      123785583..123788099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364710.1 → XP_054220685.1  protein FAM24A isoform X1

      UniProtKB/Swiss-Prot
      A6NFZ4

    2. XM_054364711.1 → XP_054220686.1  protein FAM24A isoform X1

      UniProtKB/Swiss-Prot
      A6NFZ4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NFZ4.1 GenPept UniProtKB/Swiss-Prot:A6NFZ4

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