DRG2 developmentally regulated GTP binding protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DRG2provided by HGNC
Official Full Name: developmentally regulated GTP binding protein 2provided by HGNC
Primary source: HGNC:HGNC:3030
See related: Ensembl:ENSG00000108591 MIM:602986; AllianceGenome:HGNC:3030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
Expression: Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p11.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (18087948..18107969)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (18034778..18054782)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (17991262..18011283)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
Title: Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
Title: Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
Developmentally regulated GTPases: structure, function and roles in disease.
Title: Developmentally regulated GTPases: structure, function and roles in disease.
DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression.
Title: DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression.
Knockdown of DRG2 in HeLa cells treated with epidermal growth factor (EGF) affects microtubule dynamics, perinuclear Golgi stacking, and cell migration.
Title: DRG2 knockdown induces Golgi fragmentation via GSK3β phosphorylation and microtubule stabilization.
Using immunoprecipitation, authors show that DRG2 interacts with tau, which regulates microtubule polymerization. Collectively, these data demonstrate that DRG2 may aid in affecting microtubule dynamics in HeLa cells.
Title: DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells.
Results show that the SNP (rs2257609 C>T) located in the intron region of SLC5A10 variant does not affect the expression of SLC5A10 mRNA, but alters the mRNA expression and promoter activity of DRG2. It is significantly associated with worse overall and disease-free survival of non-small-cell lung cancer (NSCLC) patients.
Title: Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer.
Taken together, our data demonstrate that DRG2 acts as a regulator of mitochondrial fission by controlling the expression of Drp1.
Title: Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1.
Authors observed that knockdown of DRG2 in HeLa cells affected growth in a wound-healing assay, and tumorigenicity in nude mice xenografts.
Title: DRG2 Regulates G2/M Progression via the Cyclin B1-Cdk1 Complex.
Results demonstrate that DRG2 is an endosomal protein and a key regulator of Rab5 deactivation and Tfn recycling.
Title: Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-13499 (e-PCR)
- UniSTS:18696

RH65958 (e-PCR)
- UniSTS:55607

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: developmentally-regulated GTP-binding protein 2

Names: TRAFAC GTPase DRG2; translation factor GTPase DRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330144.2 → NP_001317073.1 developmentally-regulated GTP-binding protein 2 isoform 2

Status: REVIEWED

Source sequence(s)

AC087164

Consensus CDS

CCDS82082.1

UniProtKB/TrEMBL

A8MZF9

Related

ENSP00000379076.4, ENST00000395726.8

Conserved Domains (4) summary

cd01896
Location:63 → 295

DRG; Developmentally Regulated GTP-binding protein (DRG)

COG1163
Location:1 → 331

Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

cl00155
Location:289 → 331

UBQ; Ubiquitin-like proteins

cl21455
Location:3 → 119

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001388.5 → NP_001379.1 developmentally-regulated GTP-binding protein 2 isoform 1

See identical proteins and their annotated locations for NP_001379.1

Status: REVIEWED

Source sequence(s)

BC000493, DA602486, X80754

Consensus CDS

CCDS11191.1

UniProtKB/Swiss-Prot

B2R8G5, P55039, Q53Y50, Q9BWB2

Related

ENSP00000225729.3, ENST00000225729.8

Conserved Domains (4) summary

cd01666
Location:289 → 363

TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...

cd01896
Location:63 → 295

DRG; Developmentally Regulated GTP-binding protein (DRG)

COG1163
Location:1 → 364

Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

cl21455
Location:3 → 119

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

18087948..18107969

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005256499.4 → XP_005256556.1 developmentally-regulated GTP-binding protein 2 isoform X1

Conserved Domains (4) summary

cd01666
Location:289 → 384

TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...

cd01896
Location:63 → 295

DRG; Developmentally Regulated GTP-binding protein (DRG)

COG1163
Location:1 → 385

Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

cl21455
Location:3 → 119

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_011523704.3 → XP_011522006.1 developmentally-regulated GTP-binding protein 2 isoform X2

Conserved Domains (4) summary

cd01896
Location:63 → 295

DRG; Developmentally Regulated GTP-binding protein (DRG)

COG1163
Location:1 → 352

Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

cl00155
Location:289 → 352

UBQ; Ubiquitin-like proteins

cl21455
Location:3 → 119

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_005256500.3 → XP_005256557.1 developmentally-regulated GTP-binding protein 2 isoform X3

Conserved Domains (2) summary

cd01666
Location:208 → 303

TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...

cd01896
Location:1 → 214

DRG; Developmentally Regulated GTP-binding protein (DRG)

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

18034778..18054782

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054315305.1 → XP_054171280.1 developmentally-regulated GTP-binding protein 2 isoform X1
XM_054315306.1 → XP_054171281.1 developmentally-regulated GTP-binding protein 2 isoform X2
XM_054315307.1 → XP_054171282.1 developmentally-regulated GTP-binding protein 2 isoform X3