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    Zfp846 zinc finger protein 846 [ Mus musculus (house mouse) ]

    Gene ID: 244721, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp846provided by MGI
    Official Full Name
    zinc finger protein 846provided by MGI
    Primary source
    MGI:MGI:1924012
    See related
    Ensembl:ENSMUSG00000058192 AllianceGenome:MGI:1924012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf846; 9130221F13; 2210010B09Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Orthologous to human ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 2.7), CNS E14 (RPKM 2.2) and 20 other tissues See more
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    Genomic context

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    See Zfp846 in Genome Data Viewer
    Location:
    9 A3; 9 7.58 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20492595..20516706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20581299..20605404)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 266 Neighboring gene predicted gene, 46142 Neighboring gene STARR-positive B cell enhancer ABC_E6716 Neighboring gene predicted gene, 51704 Neighboring gene F-box and leucine-rich repeat protein 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_23463 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene ubiquitin-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 846

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172919.2 → NP_766507.2  zinc finger protein 846

      See identical proteins and their annotated locations for NP_766507.2

      Status: VALIDATED

      Source sequence(s)
      AK033687, BB744614, BY251235, BY726782
      Consensus CDS
      CCDS22878.2
      UniProtKB/TrEMBL
      G3X996
      Related
      ENSMUSP00000111219.3, ENSMUST00000115557.10
      Conserved Domains (6) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:160 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:164 → 184
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162 → 184
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 52
      KRAB; KRAB box
      pfam13465
      Location:176 → 201
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20492595..20516706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244362.2 → XP_030100222.1  zinc finger protein 846 isoform X1

      UniProtKB/TrEMBL
      Q8BIQ2
      Conserved Domains (2) summary
      COG5048
      Location:80 → 448
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84 → 104
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_003947898.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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