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    NKIRAS1 NFKB inhibitor interacting Ras like 1 [ Homo sapiens (human) ]

    Gene ID: 28512, updated on 2-May-2024

    Summary

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    Official Symbol
    NKIRAS1provided by HGNC
    Official Full Name
    NFKB inhibitor interacting Ras like 1provided by HGNC
    Primary source
    HGNC:HGNC:17899
    See related
    Ensembl:ENSG00000197885 MIM:604496; AllianceGenome:HGNC:17899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KBRAS1; kappaB-Ras1
    Summary
    Predicted to enable GTPase activating protein binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 15.3), testis (RPKM 11.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NKIRAS1 in Genome Data Viewer
    Location:
    3p24.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (23889951..23946562, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (23894728..23951314, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23931442..23988053, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14144 Neighboring gene UBE2E1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19602 Neighboring gene ubiquitin conjugating enzyme E2 E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19605 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23906443-23907202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23924271-23924855 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:23958136-23959335 Neighboring gene uncharacterized LOC124909354 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:23987327-23987868 Neighboring gene ribosomal protein L15 Neighboring gene Sharpr-MPRA regulatory region 12700 Neighboring gene MPRA-validated peak4577 silencer Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:24023426-24023962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:24023963-24024497 Neighboring gene Sharpr-MPRA regulatory region 5785 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:24136149-24136737 Neighboring gene long intergenic non-protein coding RNA 691 Neighboring gene nucleophosmin 1 pseudogene 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prognostic significance of kappaB-Ras1 expression in gliomas. Lin H, et al. Med Oncol, 2012 Jun. PMID 21302000
    2. Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas. Gerashchenko GV, et al. Exp Oncol, 2010 Jul. PMID 20693965
    3. Upregulation of RHOA and NKIRAS1 genes in lung tumors is associated with loss of their methylation as well as with methylation of regulatory miRNA genes. Braga EA, et al. Biochemistry (Mosc), 2015 Apr. PMID 25869366
    4. [Methylation of some miRNA genes is involved in the regulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]. Khodyrev DS, et al. Mol Biol (Mosk), 2012 Sep-Oct. PMID 23156677
    5. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Chen Y, et al. Mol Cell Biol, 2004 Apr. PMID 15024091, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene.
      Title: A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene.
    2. It was demonstrated that elevated levels of mRNA for NKIRAS1 was significantly associated both with loss of methylation in NKIRAS1 CpG-islands and methylation in a number of miRNA genes.
      Title: Upregulation of RHOA and NKIRAS1 genes in lung tumors is associated with loss of their methylation as well as with methylation of regulatory miRNA genes.
    3. Significant correlation was found between alterations of methylation status of miR-34b/c, miR-193a and the expression level of NKIRAS1 target gene in the primary lung tumors.
      Title: [Methylation of some miRNA genes is involved in the regulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer].
    4. Low kappaB-Ras1 expression is associated with gliomas.
      Title: Prognostic significance of kappaB-Ras1 expression in gliomas.
    5. It was shown the decreased expression level of NKIRAS1 in Renal cell carcinoma
      Title: Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activating protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ral protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in surfactant homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    NF-kappa-B inhibitor-interacting Ras-like protein 1
    Names
    I-kappa-B-interacting Ras-like protein 1
    NFKB inhibitor interacting Ras-like protein 1
    kappa B-Ras protein 1
    kappa B-ras 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377351.1 → NP_001364280.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914, DA116722
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Related
      ENSP00000394214.2, ENST00000416026.2
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001377352.1 → NP_001364281.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001377353.1 → NP_001364282.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Related
      ENSP00000373411.3, ENST00000388759.7
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001377354.1 → NP_001364283.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001377355.1 → NP_001364284.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. NM_001377356.1 → NP_001364285.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    7. NM_001377357.1 → NP_001364286.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    8. NM_001377358.1 → NP_001364287.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    9. NM_001377359.1 → NP_001364288.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    10. NM_001377360.1 → NP_001364289.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    11. NM_001377361.1 → NP_001364290.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    12. NM_001377362.1 → NP_001364291.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    13. NM_001377363.1 → NP_001364292.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Related
      ENSP00000483749.1, ENST00000614374.4
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    14. NM_001377364.1 → NP_001364293.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    15. NM_001377365.1 → NP_001364294.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Conserved Domains (1) summary
      cl38936
      Location:6 → 136
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    16. NM_001377366.1 → NP_001364295.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Conserved Domains (1) summary
      cl38936
      Location:6 → 136
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    17. NM_001377367.1 → NP_001364296.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Conserved Domains (1) summary
      cl38936
      Location:6 → 136
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    18. NM_001377368.1 → NP_001364297.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Conserved Domains (1) summary
      cl38936
      Location:6 → 136
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    19. NM_001377369.1 → NP_001364298.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Conserved Domains (1) summary
      cl38936
      Location:6 → 111
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    20. NM_001377370.1 → NP_001364299.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Conserved Domains (1) summary
      cl38936
      Location:6 → 136
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    21. NM_001377371.1 → NP_001364300.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Conserved Domains (1) summary
      cl38936
      Location:6 → 136
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    22. NM_001377372.1 → NP_001364301.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Conserved Domains (1) summary
      cl38936
      Location:6 → 136
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    23. NM_001377380.1 → NP_001364309.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Related
      ENSP00000392307.2, ENST00000421515.6
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    24. NM_020345.4 → NP_065078.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_065078.1

      Status: VALIDATED

      Source sequence(s)
      AC124914, BC012145, BG713995
      Consensus CDS
      CCDS33717.1
      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Related
      ENSP00000400385.2, ENST00000425478.7
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      23889951..23946562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447998.1 → XP_047303954.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0

    2. XM_047447999.1 → XP_047303955.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0

    3. XM_024453460.2 → XP_024309228.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
      Related
      ENSP00000393785.2, ENST00000443659.6
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      23894728..23951314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346244.1 → XP_054202219.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0

    2. XM_054346245.1 → XP_054202220.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0

    3. XM_054346246.1 → XP_054202221.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q96K18, Q9NYS0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYS0.1 GenPept UniProtKB/Swiss-Prot:Q9NYS0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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