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    pyc-1 Pyruvate carboxylase 1;Pyruvate carboxylase subunit B [ Caenorhabditis elegans ]

    Gene ID: 179616, updated on 12-Jun-2024

    Summary

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    Gene symbol
    pyc-1
    Gene description
    Pyruvate carboxylase 1;Pyruvate carboxylase subunit B
    Locus tag
    CELE_D2023.2
    See related
    AllianceGenome:WB:WBGene00004258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable pyruvate carboxylase activity. Predicted to be involved in gluconeogenesis and pyruvate metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See pyc-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (11817783..11822365, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Thialysine N-epsilon-acetyltransferase Neighboring gene Putative thiosulfate sulfurtransferase mpst-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a cadmium-inducible isoform of pyruvate carboxylase from Caenorhabditis elegans. Liao VH, et al. DNA Seq, 2001. PMID 11761713
    2. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Wirth M, et al. Mitochondrion, 2013 Nov. PMID 23438705, Free PMC Article
    3. Global analysis of dauer gene expression in Caenorhabditis elegans. Wang J, et al. Development, 2003 Apr. PMID 12620986
    4. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Mouchiroud L, et al. Cell, 2013 Jul 18. PMID 23870130, Free PMC Article
    5. Mass spectrometric proteome analysis for profiling temperature-dependent changes of protein expression in wild-type Caenorhabditis elegans. Mádi A, et al. Proteomics, 2003 Aug. PMID 12923778

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Pyruvate carboxylase 1;Pyruvate carboxylase subunit B
    NP_001368099.1
    • Confirmed by transcript evidence
    NP_001369995.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11817783..11822365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383412.2 → NP_001369995.1  Pyruvate carboxylase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17732
      Conserved Domains (1) summary
      PRK12999
      Location:28 → 1175
      PRK12999; pyruvate carboxylase; Reviewed

    2. NM_001380776.1 → NP_001368099.1  Pyruvate carboxylase subunit B [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2E4
      Conserved Domains (1) summary
      cl39082
      Location:2 → 616
      PycA; Pyruvate carboxylase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17732.1

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