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    Lrrc40 leucine rich repeat containing 40 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310946, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Lrrc40provided by RGD
    Official Full Name
    leucine rich repeat containing 40provided by RGD
    Primary source
    RGD:1562017
    See related
    Ensembl:ENSRNOG00000011555 AllianceGenome:RGD:1562017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human LRRC40 (leucine rich repeat containing 40). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 100.1), Thymus (RPKM 99.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc40 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (249760354..249789897)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (247101518..247131061)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (264864321..264894588)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 19 Neighboring gene ankyrin repeat domain 13C Neighboring gene serine and arginine rich splicing factor 11 Neighboring gene leucine rich repeat containing 7 Neighboring gene transfer RNA alanine (anticodon AGC) 26 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125134

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034926.2 → NP_001030098.2  leucine-rich repeat-containing protein 40 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GL58, A6HWT9, G3V7I7, Q3KR61
      Related
      ENSRNOP00000015434.6, ENSRNOT00000015434.7
      Conserved Domains (2) summary
      PLN00113
      Location:89 → 577
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:84 → 106
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_001399478.1 → NP_001386407.1  leucine-rich repeat-containing protein 40 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AEF1, A0A8I6GL58
      Related
      ENSRNOP00000091411.1, ENSRNOT00000115272.1
      Conserved Domains (2) summary
      PLN00113
      Location:89 → 541
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:107 → 129
      LRR_RI; leucine-rich repeat [structural motif]

    3. NM_001399479.1 → NP_001386408.1  leucine-rich repeat-containing protein 40 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWU1
      Conserved Domains (2) summary
      PLN00113
      Location:3 → 454
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:7 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    4. NM_001399480.1 → NP_001386409.1  leucine-rich repeat-containing protein 40 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Conserved Domains (2) summary
      PLN00113
      Location:2 → 436
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:12 → 34
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      249760354..249789897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281983.1 → XP_063138053.1  leucine-rich repeat-containing protein 40 isoform X1

      UniProtKB/TrEMBL
      A6HWU1

    2. XM_039102491.2 → XP_038958419.1  leucine-rich repeat-containing protein 40 isoform X2

      Conserved Domains (2) summary
      PLN00113
      Location:2 → 436
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:12 → 34
      LRR_RI; leucine-rich repeat [structural motif]

    3. XM_063281984.1 → XP_063138054.1  leucine-rich repeat-containing protein 40 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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