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    Tbx22 T-box transcription factor 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302369, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tbx22provided by RGD
    Official Full Name
    T-box transcription factor 22provided by RGD
    Primary source
    RGD:1589764
    See related
    Ensembl:ENSRNOG00000002346 AllianceGenome:RGD:1589764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tbx 22
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and cleft palate. Orthologous to human TBX22 (T-box transcription factor 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 27.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbx22 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (76796398..76847447)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (72723619..72774647)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (78731738..78782542)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene prohibitin 1, pseudogene 10 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 17 Neighboring gene putative transmembrane protein 217B Neighboring gene forkhead box N2, pseudogene 1 Neighboring gene charged multivesicular body protein 1B2 Neighboring gene terminal nucleotidyltransferase 5D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression. Andreou AM, et al. Am J Hum Genet, 2007 Oct. PMID 17846996, Free PMC Article
    2. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. Braybrook C, et al. Hum Mol Genet, 2002 Oct 15. PMID 12374769
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-box transcription factor TBX22
    Names
    T-box 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106937.1 → NP_001100407.1  T-box transcription factor TBX22

      See identical proteins and their annotated locations for NP_001100407.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473969
      UniProtKB/TrEMBL
      A6IV69, D3ZMK6
      Related
      ENSRNOP00000003190.4, ENSRNOT00000003190.6
      Conserved Domains (1) summary
      cd00182
      Location:90 → 285
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      76796398..76847447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257159.5 → XP_006257221.1  T-box transcription factor TBX22 isoform X1

      See identical proteins and their annotated locations for XP_006257221.1

      Conserved Domains (1) summary
      cd00182
      Location:105 → 300
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    2. XM_006257161.5 → XP_006257223.1  T-box transcription factor TBX22 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JUM5
      Related
      ENSRNOP00000069154.2
      Conserved Domains (1) summary
      cd00182
      Location:104 → 299
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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