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    Deup1 deuterosome assembly protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 234964, updated on 8-May-2024

    Summary

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    Official Symbol
    Deup1provided by MGI
    Official Full Name
    deuterosome assembly protein 1provided by MGI
    Primary source
    MGI:MGI:2443026
    See related
    Ensembl:ENSMUSG00000039977 AllianceGenome:MGI:2443026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc67; 4933401K09Rik
    Summary
    Predicted to enable identical protein binding activity. Involved in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Located in deuterosome. Is expressed in several structures, including brain; male reproductive gland or organ; olfactory epithelium; respiratory system; and thyroid gland. Orthologous to human DEUP1 (deuterosome assembly protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 25.8) See more
    Orthologs
    human all
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    Genomic context

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    See Deup1 in Genome Data Viewer
    Location:
    9 A2; 9 5.0 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15471160..15539646, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15559864..15628351, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene single-pass membrane protein with coiled-coil domains 4 Neighboring gene predicted gene, 35176 Neighboring gene STARR-positive B cell enhancer ABC_E2281 Neighboring gene predicted gene, 51703 Neighboring gene STARR-seq mESC enhancer starr_23385 Neighboring gene predicted gene, 46152 Neighboring gene STARR-seq mESC enhancer starr_23386 Neighboring gene RIKEN cDNA 4930540M03 gene Neighboring gene predicted gene, 39295 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene predicted gene, 35225

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis. Yamamoto S, et al. Biol Open, 2021 Mar 3. PMID 33658185, Free PMC Article
    2. Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Mercey O, et al. Nat Cell Biol, 2019 Dec. PMID 31792378, Free PMC Article
    3. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Zhao H, et al. Nat Cell Biol, 2013 Dec. PMID 24240477
    4. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. Oduru S, et al. BMC Genomics, 2003 Jun 3. PMID 12783626, Free PMC Article
    5. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Otto T, et al. Proc Natl Acad Sci U S A, 2017 Oct 3. PMID 28923932, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deup1 Expression Interferes with Multiciliated Differentiation.
      Title: Deup1 Expression Interferes with Multiciliated Differentiation.
    2. Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis.
      Title: Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis.
    3. Deup1 governs deuterosome assembly to mediate large-scale de novo centriole biogenesis.
      Title: The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in multi-ciliated epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in deuterosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in deuterosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deuterosome assembly protein 1
    Names
    coiled-coil domain containing 67
    coiled-coil domain-containing protein 67
    deuterosomal protein 1
    deuterosome protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001373917.1 → NP_001360846.1  deuterosome assembly protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC155249
      Consensus CDS
      CCDS90502.1
      UniProtKB/Swiss-Prot
      E9QL16, Q4VA46, Q7M6Y5
      Related
      ENSMUSP00000039912.7, ENSMUST00000045513.13
      Conserved Domains (2) summary
      PRK03918
      Location:211 → 466
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    2. NM_001373918.1 → NP_001360847.1  deuterosome assembly protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC155249
      Conserved Domains (2) summary
      PRK03918
      Location:220 → 445
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:1 → 258
      CEP63; Centrosomal protein of 63 kDa

    3. NM_001373919.1 → NP_001360848.1  deuterosome assembly protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC155249
      Conserved Domains (2) summary
      PRK03918
      Location:209 → 434
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:12 → 247
      CEP63; Centrosomal protein of 63 kDa

    4. NM_001373920.1 → NP_001360849.1  deuterosome assembly protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC155249
      UniProtKB/TrEMBL
      U5KUF9
      Conserved Domains (1) summary
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    5. NM_001373921.1 → NP_001360850.1  deuterosome assembly protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC155249
      UniProtKB/TrEMBL
      D3Z2N8
      Related
      ENSMUSP00000121526.2, ENSMUST00000152377.2
      Conserved Domains (2) summary
      PRK03918
      Location:241 → 409
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    6. NM_181816.3 → NP_861537.2  deuterosome assembly protein 1 isoform 5

      See identical proteins and their annotated locations for NP_861537.2

      Status: VALIDATED

      Source sequence(s)
      AC155249
      Consensus CDS
      CCDS22839.2
      UniProtKB/Swiss-Prot
      Q7M6Y5
      Related
      ENSMUSP00000111256.4, ENSMUST00000115593.10
      Conserved Domains (1) summary
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      15471160..15539646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510165.3 → XP_006510228.1  deuterosome assembly protein 1 isoform X3

      Conserved Domains (2) summary
      PRK03918
      Location:211 → 466
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    2. XM_036154860.1 → XP_036010753.1  deuterosome assembly protein 1 isoform X5

      Conserved Domains (1) summary
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    3. XM_006510166.3 → XP_006510229.1  deuterosome assembly protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006510229.1

      UniProtKB/TrEMBL
      U5KUF9
      Conserved Domains (1) summary
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    4. XM_006510159.4 → XP_006510222.1  deuterosome assembly protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006510222.1

      UniProtKB/Swiss-Prot
      E9QL16, Q4VA46, Q7M6Y5
      Conserved Domains (2) summary
      PRK03918
      Location:211 → 466
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    5. XM_030244280.2 → XP_030100140.1  deuterosome assembly protein 1 isoform X4

      UniProtKB/TrEMBL
      U5KUF9
      Conserved Domains (1) summary
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    6. XM_011242458.3 → XP_011240760.1  deuterosome assembly protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011240760.1

      Conserved Domains (2) summary
      PRK03918
      Location:220 → 445
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:1 → 258
      CEP63; Centrosomal protein of 63 kDa

    7. XM_006510163.4 → XP_006510226.1  deuterosome assembly protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006510226.1

      Conserved Domains (2) summary
      PRK03918
      Location:220 → 445
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:1 → 258
      CEP63; Centrosomal protein of 63 kDa

    8. XM_006510164.4 → XP_006510227.1  deuterosome assembly protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006510227.1

      Conserved Domains (2) summary
      PRK03918
      Location:220 → 445
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:1 → 258
      CEP63; Centrosomal protein of 63 kDa

    9. XM_011242457.3 → XP_011240759.1  deuterosome assembly protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011240759.1

      Conserved Domains (2) summary
      PRK03918
      Location:220 → 445
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:1 → 258
      CEP63; Centrosomal protein of 63 kDa

    10. XM_006510161.4 → XP_006510224.1  deuterosome assembly protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006510224.1

      Conserved Domains (2) summary
      PRK03918
      Location:220 → 445
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam17045
      Location:1 → 258
      CEP63; Centrosomal protein of 63 kDa

    RNA

    1. XR_003947864.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M6Y5.3 GenPept UniProtKB/Swiss-Prot:Q7M6Y5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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