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    Yaf2 YY1 associated factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 67057, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Yaf2provided by MGI
    Official Full Name
    YY1 associated factor 2provided by MGI
    Primary source
    MGI:MGI:1914307
    See related
    Ensembl:ENSMUSG00000022634 AllianceGenome:MGI:1914307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810021M11Rik
    Summary
    Predicted to enable DNA binding activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription, DNA-templated and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including cranial ganglion; early conceptus; embryo mesenchyme; genitourinary system; and heart. Orthologous to human YAF2 (YY1 associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 27.2), frontal lobe adult (RPKM 27.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Yaf2 in Genome Data Viewer
    Location:
    15 E3; 15 47.39 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (93181714..93234816, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (93283833..93336935, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38535 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glucoside xylosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E945 Neighboring gene predicted gene, 52193 Neighboring gene predicted gene, 26371 Neighboring gene STARR-seq mESC enhancer starr_39524 Neighboring gene zinc finger CCHC-type and RNA binding motif 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division. Zhao J, et al. Nat Cell Biol, 2020 Apr. PMID 32203418
    2. Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice. Solca C, et al. J Lipid Res, 2013 Feb. PMID 23180829, Free PMC Article
    3. Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis. Eid A, et al. Epigenetics, 2016 Jun 2. PMID 27081692, Free PMC Article
    4. The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos. Kaneko T, et al. Gene, 2003 Oct 2. PMID 14557078
    5. RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. Rose NR, et al. Elife, 2016 Oct 5. PMID 27705745, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
      Title: Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
    2. The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
      Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
    3. Yaf2 acts as a functional, likely molecular, link between YY1 and the Polycomb proteins. It is proposed to mediate the DNA binding activity of YY1 and recruitment of Polycomb proteins to the regulatory region of target genes.
      Title: PcG recruitment by the YY1 REPO domain can be mediated by Yaf2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    YY1-associated factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024189.6 → NP_077151.3  YY1-associated factor 2

      See identical proteins and their annotated locations for NP_077151.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and is protein-coding.
      Source sequence(s)
      AK011702, AK148634
      Consensus CDS
      CCDS27765.1
      UniProtKB/Swiss-Prot
      Q3UFD4, Q99LW6, Q9DBE4
      Related
      ENSMUSP00000079179.7, ENSMUST00000080299.7
      Conserved Domains (2) summary
      sd00029
      Location:23 → 42
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:20 → 43
      zf-RanBP; Zn-finger in Ran binding protein and others

    RNA

    1. NR_028315.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon resulting in a frameshift and early stop codon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK011702, AK148634
      Related
      ENSMUST00000133736.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      93181714..93234816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521292.4 → XP_006521355.1  YY1-associated factor 2 isoform X1

      Conserved Domains (3) summary
      sd00029
      Location:23 → 42
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:20 → 43
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam17219
      Location:126 → 156
      YAF2_RYBP; Yaf2/RYBP C-terminal binding motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LW6.1 GenPept UniProtKB/Swiss-Prot:Q99LW6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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