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    CCDC106 coiled-coil domain containing 106 [ Homo sapiens (human) ]

    Gene ID: 29903, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CCDC106provided by HGNC
    Official Full Name
    coiled-coil domain containing 106provided by HGNC
    Primary source
    HGNC:HGNC:30181
    See related
    Ensembl:ENSG00000173581 MIM:613478; AllianceGenome:HGNC:30181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF581; HSU79303
    Summary
    Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 7.5), brain (RPKM 6.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCDC106 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55647400..55653161)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58743329..58749089)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56158766..56164527)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107983998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15101 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:56146823-56146990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11051 Neighboring gene zinc finger protein 581 Neighboring gene Sharpr-MPRA regulatory region 1979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56155949-56156914 Neighboring gene zinc finger protein 580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15107 Neighboring gene U2 small nuclear RNA auxiliary factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11061 Neighboring gene Sharpr-MPRA regulatory region 14549 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56192159-56192659 Neighboring gene epsin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56213120-56214004 Neighboring gene vomeronasal 1 receptor 106 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing. Zhi W, et al. J Med Virol, 2023 Jan. PMID 35854676, Free PMC Article
    2. CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway. Zhao N, et al. Bioengineered, 2022 Apr. PMID 35484984, Free PMC Article
    3. CCDC106 promotes non-small cell lung cancer cell proliferation. Zhang X, et al. Oncotarget, 2017 Apr 18. PMID 28460455, Free PMC Article
    4. HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer. Cao C, et al. J Genet Genomics, 2020 Aug. PMID 33023834
    5. Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation. Zhou J, et al. FEBS Lett, 2010 Mar 19. PMID 20159018

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing.
      Title: HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing.
    2. CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway.
      Title: CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway.
    3. HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.
      Title: HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.
    4. Study revealed a CK2/CCDC106/p53 signaling axis in the progression of breast and cervical cancers.
      Title: CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression.
    5. Our studies revealed that CCDC106 is associated with non-small cell lung cancer progression and unfavorable prognosis. CCDC106 enhanced Cyclin A2 and Cyclin B1 expression and promoted A549 and H1299 cell proliferation, which depended on AKT signaling. These results suggest that CCDC106 may be a novel target for lung cancer treatment.
      Title: CCDC106 promotes non-small cell lung cancer cell proliferation.
    6. CCDC106 promotes the degradation of p53 protein and inhibits its transactivity.
      Title: Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 106
    Names
    protein predicted by clone 23882

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370467.1 → NP_001357396.1  coiled-coil domain-containing protein 106 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008735, GU354321
      Consensus CDS
      CCDS33118.1
      UniProtKB/Swiss-Prot
      B3KUF9, D3K183, Q99786, Q9BWC9
      Conserved Domains (1) summary
      pfam15794
      Location:55 → 276
      CCDC106; Coiled-coil domain-containing protein 106

    2. NM_001370468.1 → NP_001357397.1  coiled-coil domain-containing protein 106 isoform 1

      Status: VALIDATED

      Source sequence(s)
      DA360854, GU354322
      Consensus CDS
      CCDS33118.1
      UniProtKB/Swiss-Prot
      B3KUF9, D3K183, Q99786, Q9BWC9
      Related
      ENSP00000468539.1, ENST00000588740.5
      Conserved Domains (1) summary
      pfam15794
      Location:55 → 276
      CCDC106; Coiled-coil domain-containing protein 106

    3. NM_001370469.1 → NP_001357398.1  coiled-coil domain-containing protein 106 isoform 1

      Status: VALIDATED

      Source sequence(s)
      DA360854, GU354323
      Consensus CDS
      CCDS33118.1
      UniProtKB/Swiss-Prot
      B3KUF9, D3K183, Q99786, Q9BWC9
      Related
      ENSP00000466870.1, ENST00000591578.5
      Conserved Domains (1) summary
      pfam15794
      Location:55 → 276
      CCDC106; Coiled-coil domain-containing protein 106

    4. NM_001370470.1 → NP_001357399.1  coiled-coil domain-containing protein 106 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008735, BI755544, GU354323
      Consensus CDS
      CCDS33118.1
      UniProtKB/Swiss-Prot
      B3KUF9, D3K183, Q99786, Q9BWC9
      Related
      ENSP00000465757.1, ENST00000586790.6
      Conserved Domains (1) summary
      pfam15794
      Location:55 → 276
      CCDC106; Coiled-coil domain-containing protein 106

    5. NM_001370471.1 → NP_001357400.1  coiled-coil domain-containing protein 106 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008735
      Consensus CDS
      CCDS92692.1
      UniProtKB/TrEMBL
      K7EMI9
      Related
      ENSP00000466521.1, ENST00000591241.1
      Conserved Domains (1) summary
      pfam15794
      Location:20 → 241
      CCDC106; Coiled-coil domain-containing protein 106

    6. NM_013301.2 → NP_037433.2  coiled-coil domain-containing protein 106 isoform 1

      See identical proteins and their annotated locations for NP_037433.2

      Status: VALIDATED

      Source sequence(s)
      AC008735, AF054984, BI907663
      Consensus CDS
      CCDS33118.1
      UniProtKB/Swiss-Prot
      B3KUF9, D3K183, Q99786, Q9BWC9
      Related
      ENSP00000309681.2, ENST00000308964.7
      Conserved Domains (1) summary
      pfam15794
      Location:55 → 276
      CCDC106; Coiled-coil domain-containing protein 106

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55647400..55653161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58743329..58749089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BWC9.1 GenPept UniProtKB/Swiss-Prot:Q9BWC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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